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Cellosaurus B-CPAP (CVCL_0153)

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Cell line name B-CPAP
Synonyms BC-PAP; BCPAP
Accession CVCL_0153
Resource Identification Initiative To cite this cell line use: B-CPAP (RRID:CVCL_0153)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: TCGA-110-CL cell line panel.
Population: Caucasian.
Doubling time: ~30 hours (DSMZ=ACC-273).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Caution: Originally classified a thyroid gland papillary carcinoma (PTC) but is now considered to be a poorly differentiated thyroid gland carcinoma (PDTC) (PubMed=23162534).
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,33:01
HLA-BB*18:01,35:01
HLA-CC*04:01,07:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.56
Native American1.26
East Asian, North0.45
East Asian, South1.09
South Asian1.92
European, North43.75
European, South50.97
Disease Poorly differentiated thyroid gland carcinoma (NCIt: C6040)
Thyroid carcinoma (ORDO: Orphanet_100088)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A8S1 (BCPAP-R)
Sex of cell Female
Age at sampling 76Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=924104; DSMZ=ACC-273; PubMed=18713817; PubMed=21868764; PubMed=25877200; PubMed=30737244

Markers:
AmelogeninX
CSF1PO13
D2S133818
D3S135816,17
D5S81810,11
D7S82010
D8S117912,13
D13S31712
D16S53911,12
D18S5113,17
D19S43313.2,15 (PubMed=25877200)
14,15 (DSMZ=ACC-273)
D21S1130 (DSMZ=ACC-273)
30,31.2 (PubMed=18713817; PubMed=25877200; PubMed=30737244)
FGA20,23
Penta D10,11
Penta E5,12 (DSMZ=ACC-273)
5,12,17 (PubMed=25877200)
TH016,9.3
TPOX8,11
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=1297527
Christian Paulin, Nicole Fabien, Alfredo Fusco, Marie-Pierre Pages, Marie-Claude Patricot, Hubert Bornet, Paul-Marie Dubois;
Description of a cell line established from a human thyroid papillary carcinoma and synthesizing human chorionic gonadotropin hormone.
C. R. Acad. Sci. III, Sci. Vie 315:493-498(1992)

PubMed=8156527; DOI=10.1002/1097-0142(19940415)73:8<2206::AID-CNCR2820730828>3.0.CO;2-M
Nicole Fabien, Alfredo Fusco, Massimo Mattia Santoro, Yves Barbier, Paul-Marie Dubois, Christian Paulin;
Description of a human papillary thyroid carcinoma cell line Morphologic study and expression of tumoral markers.
Cancer 73:2206-2212(1994)

PubMed=11439348; DOI=10.1038/sj.onc.1204531
Francesco Frasca, Paolo Vigneri, Veronica Vella, Riccardo Vigneri, Jean Y.-J. Wang;
Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to hepatocyte growth factor.
Oncogene 20:3845-3856(2001)

PubMed=14522906
Francesco Frasca, Veronica Vella, Alessandra Aloisi, Angelo Mandarino, Emanuela Mazzon, Riccardo Vigneri, Paolo Vigneri;
p73 tumor-suppressor activity is impaired in human thyroid cancer.
Cancer Res. 63:5829-5837(2003)

PubMed=15172756; DOI=10.1016/j.cancergencyto.2003.09.023
Tinuccia Dettori, Daniela Virginia Frau, Juan L. Garcia, Giovanna Maria Pierantoni, Charles Lee, Jesus Maria Hernandez-Rivas, Alfredo Fusco, Cynthia Casson Morton, Roberta Vanni;
Comprehensive conventional and molecular cytogenetic characterization of B-CPAP, a human papillary thyroid carcinoma-derived cell line.
Cancer Genet. Cytogenet. 151:171-177(2004)

PubMed=17725429; DOI=10.1089/thy.2007.0097
Ana Margarida Meireles, Ana Preto, Ana Sofia Rocha, Ana Paula Rebocho, Valdemar Maximo, Isabel Pereira-Castro, Severina Moreira, Talia Feijao, Tiago Botelho, Ricardo Marques, Vitor Trovisco ...Show all 16 authors... , Luis Cirnes, Cintia Alves, Sergia Velho, Paula Soares, Manuel Sobrinho-Simoes; Show fewer authors
Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.
Thyroid 17:707-715(2007)

PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026
Wilma C.G. van Staveren, David Y. Weiss-Solis, Laurent Delys, Laurence Duprez, Guy Andry, Brigitte Franc, Gerry Thomas, Frederick Libert, Jacques-Emile Dumont, Vincent Detours, Carine Maenhaut;
Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.
Cancer Res. 67:8113-8120(2007)

PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569
Rebecca E. Schweppe, Joshua P. Klopper, Christopher T. Korch, Umarani Pugazhenthi, Miriam Benezra, Jeffrey A. Knauf, James Alexander Fagin, Laura A. Marlow, John Alton Copland 3rd, Robert Christian Smallridge, Bryan R. Haugen;
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=19087340; DOI=10.1186/1471-2407-8-371; PMCID=PMC2651892
Franclim Ricardo Ribeiro, Ana Margarida Meireles, Ana Sofia Rocha, Manuel R. Teixeira;
Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples.
BMC Cancer 8:371.1-371.11(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=22087789; DOI=10.1186/1755-8166-4-26; PMCID=PMC3248874
Irena Maric, Silvia Viaggi, Paola Caria, Daniela Virginia Frau, Paolo Degan, Roberta Vanni;
Centrosomal and mitotic abnormalities in cell lines derived from papillary thyroid cancer harboring specific gene alterations.
Mol. Cytogenet. 4:26.1-26.8(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23162534; DOI=10.3389/fendo.2012.00133; PMCID=PMC3499787
Manuel Saiselet, Sebastien Floor, Maxime Tarabichi, Genevieve Dom, Aline Hebrant, Wilma C.G. van Staveren, Carine Maenhaut;
Thyroid cancer cell lines: an overview.
Front. Endocrinol. 3:133.1-133.9(2012)

PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971
Inigo Landa, Ian Ganly, Timothy A. Chan, Norisato Mitsutake, Michiko Matsuse, Tihana Ibrahimpasic, Ronald A. Ghossein, James Alexander Fagin;
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28775782; DOI=10.7150/jca.18855; PMCID=PMC5535718
Paola Caria, Rita Pillai, Tinuccia Dettori, Daniela Virginia Frau, Patrizia Zavattari, Gabriele Riva, Gabriele Romano, Fabiana Pani, Angela Bentivegna, Roberto Giovannoni, Fabio Pagni ...Show all 13 authors... , Valeria Sogos, Roberta Vanni; Show fewer authors
Thyrospheres from B-CPAP cell line with BRAF and TERT promoter mutations have different functional and molecular features than parental cells.
J. Cancer 8:1629-1639(2017)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785
Katharine Yu, Bin Chen, Dvir Aran, Joe Charalel, Christina Yau, Douglas M. Wolf, Laura J. van 't Veer, Atul Janardhan Butte, Ted Goldstein, Marina Sirota;
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

PubMed=32666385; DOI=10.1007/s12020-020-02417-y
Lin Run, Li-Ping Wang, Xi-Ting Nong, Nan Li, Xin Huang, Yang Xiao;
Involvement of HMGB1 in vemurafenib resistance in thyroid cancer cells harboring BRAF (V600E) mutation by regulating excessive autophagy.
Endocrine 71:418-426(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) CLS; 305081
DSMZ; ACC-273
NCBI_Iran; C596
Cell line databases/resources CLO; CLO_0001906
MCCL; MCC:0000045
cancercelllines; CVCL_0153
CCRID; 3101HUMSCSP543
Cell_Model_Passport; SIDM00992
Cosmic-CLP; 924104
DepMap; ACH-000456
DSMZCellDive; ACC-273
LINCS_LDP; LCL-1687
Anatomy/cell type resources BTO; BTO_0004736
Biological sample resources BioSample; SAMN03471001
BioSample; SAMN10989558
Chemistry resources ChEMBL-Cells; CHEMBL3308356
ChEMBL-Targets; CHEMBL1075394
GDSC; 924104
PharmacoDB; BCPAP_82_2019
PubChem_Cell_line; CVCL_0153
Encyclopedic resources Wikidata; Q54752132
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM886875
GEO; GSM887940
GEO; GSM1669612
Polymorphism and mutation databases Cosmic; 755292
Cosmic; 849970
Cosmic; 924104
Cosmic; 928836
Cosmic; 931241
Cosmic; 1084279
Cosmic; 1162847
Cosmic; 1237447
Cosmic; 1239965
Cosmic; 1280047
Cosmic; 1507369
Cosmic; 1533552
Cosmic; 1536122
Cosmic; 1889007
Cosmic; 2036692
Cosmic; 2054086
Cosmic; 2319847
Cosmic; 2613253
Cosmic; 2791089
IARC_TP53; 25011
LiGeA; CCLE_362
Progenetix; CVCL_0153
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number43