ID B-CPAP AC CVCL_0153 SY BC-PAP; BCPAP DR BTO; BTO_0004736 DR CLO; CLO_0001906 DR MCCL; MCC:0000045 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioSample; SAMN03471001 DR BioSample; SAMN10989558 DR cancercelllines; CVCL_0153 DR CCRID; 3101HUMSCSP543 DR Cell_Model_Passport; SIDM00992 DR ChEMBL-Cells; CHEMBL3308356 DR ChEMBL-Targets; CHEMBL1075394 DR CLS; 305081 DR Cosmic; 755292 DR Cosmic; 849970 DR Cosmic; 924104 DR Cosmic; 928836 DR Cosmic; 931241 DR Cosmic; 1084279 DR Cosmic; 1162847 DR Cosmic; 1237447 DR Cosmic; 1239965 DR Cosmic; 1280047 DR Cosmic; 1507369 DR Cosmic; 1533552 DR Cosmic; 1536122 DR Cosmic; 1889007 DR Cosmic; 2036692 DR Cosmic; 2054086 DR Cosmic; 2319847 DR Cosmic; 2613253 DR Cosmic; 2791089 DR Cosmic-CLP; 924104 DR DepMap; ACH-000456 DR DSMZ; ACC-273 DR DSMZCellDive; ACC-273 DR EGA; EGAS00001000978 DR GDSC; 924104 DR GEO; GSM886875 DR GEO; GSM887940 DR GEO; GSM1669612 DR IARC_TP53; 25011 DR LiGeA; CCLE_362 DR LINCS_LDP; LCL-1687 DR NCBI_Iran; C596 DR PharmacoDB; BCPAP_82_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_0153 DR PubChem_Cell_line; CVCL_0153 DR Wikidata; Q54752132 RX PubMed=1297527; RX PubMed=8156527; RX PubMed=11439348; RX PubMed=14522906; RX PubMed=15172756; RX PubMed=17725429; RX PubMed=17804723; RX PubMed=18713817; RX PubMed=19087340; RX PubMed=20164919; RX PubMed=21868764; RX PubMed=22087789; RX PubMed=22460905; RX PubMed=23162534; RX PubMed=23833040; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=28775782; RX PubMed=30737244; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31395879; RX PubMed=32666385; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: TCGA-110-CL cell line panel. CC Population: Caucasian. CC Doubling time: ~30 hours (DSMZ=ACC-273). CC HLA typing: A*02:01,33:01; B*18:01,35:01; C*04:01,07:01 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (PubMed=23162534; PubMed=23833040; PubMed=30737244; Cosmic-CLP=924104; DepMap=ACH-000456). CC Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040; PubMed=30737244). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asp259Tyr (c.775G>T); ClinVar=VCV000634680; Zygosity=Homozygous (PubMed=14522906; PubMed=23162534; PubMed=30737244; Cosmic-CLP=924104; DepMap=ACH-000456). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.56%; Native American=1.26%; East Asian, North=0.45%; East Asian, South=1.09%; South Asian=1.92%; European, North=43.75%; European, South=50.97% (PubMed=30894373). CC Caution: Originally classified a thyroid gland papillary carcinoma (PTC) but is now considered to be a poorly differentiated thyroid gland carcinoma (PDTC) (PubMed=23162534). CC Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046. ST Source(s): Cosmic-CLP=924104; DSMZ=ACC-273; PubMed=18713817; PubMed=21868764; PubMed=25877200; PubMed=30737244 ST Amelogenin: X ST CSF1PO: 13 ST D13S317: 12 ST D16S539: 11,12 ST D18S51: 13,17 ST D19S433: 13.2,15 (PubMed=25877200) ST D19S433: 14,15 (DSMZ=ACC-273) ST D21S11: 30 (DSMZ=ACC-273) ST D21S11: 30,31.2 (PubMed=18713817; PubMed=25877200; PubMed=30737244) ST D2S1338: 18 ST D3S1358: 16,17 ST D5S818: 10,11 ST D7S820: 10 ST D8S1179: 12,13 ST FGA: 20,23 ST Penta D: 10,11 ST Penta E: 5,12 (DSMZ=ACC-273) ST Penta E: 5,12,17 (PubMed=25877200) ST TH01: 6,9.3 ST TPOX: 8,11 ST vWA: 14,17 DI NCIt; C6040; Poorly differentiated thyroid gland carcinoma DI ORDO; Orphanet_100088; Thyroid carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 76Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 43 CH CVCL_A8S1 ! BCPAP-R CH CVCL_F1MW ! HyCyte B-CPAP KO-hSLC5A5 // RX PubMed=32666385; DOI=10.1007/s12020-020-02417-y; RA Run, Lin RA Wang, Li-Ping RA Nong, Xi-Ting RA Li, Nan RA Huang, Xin RA Xiao, Yang RT "Involvement of HMGB1 in vemurafenib resistance in thyroid cancer RT cells harboring BRAF (V600E) mutation by regulating excessive RT autophagy."; RL Endocrine 71:418-426(2021). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662; RA Zhao, Mei RA Sano, Daisuke RA Pickering, Curtis R. RA Jasser, Samar A. RA Henderson, Ying C. RA Clayman, Gary L. RA Sturgis, Erich M. RA Ow, Thomas J. RA Lotan, Reuben RA Carey, Thomas E. RA Sacks, Peter G. RA Grandis, Jennifer Rubin RA Sidransky, David RA Heldin, Nils-Erik RA Myers, Jeffrey N. RT "Assembly and initial characterization of a panel of 85 genomically RT validated cell lines from diverse head and neck tumor sites."; RL Clin. Cancer Res. 17:7248-7264(2011). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=22087789; DOI=10.1186/1755-8166-4-26; PMCID=PMC3248874; RA Maric, Irena RA Viaggi, Silvia RA Caria, Paola RA Frau, Daniela Virginia RA Degan, Paolo RA Vanni, Roberta RT "Centrosomal and mitotic abnormalities in cell lines derived from RT papillary thyroid cancer harboring specific gene alterations."; RL Mol. Cytogenet. 4:26.1-26.8(2011). // RX PubMed=11439348; DOI=10.1038/sj.onc.1204531; RA Frasca, Francesco RA Vigneri, Paolo RA Vella, Veronica RA Vigneri, Riccardo RA Wang, Jean Yin-Jen RT "Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile RT response to hepatocyte growth factor."; RL Oncogene 20:3845-3856(2001). // RX PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971; RA Landa, Inigo RA Ganly, Ian RA Chan, Timothy A. RA Mitsutake, Norisato RA Matsuse, Michiko RA Ibrahimpasic, Tihana RA Ghossein, Ronald A. RA Fagin, James Alexander RT "Frequent somatic TERT promoter mutations in thyroid cancer: higher RT prevalence in advanced forms of the disease."; RL J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013). // RX PubMed=23162534; DOI=10.3389/fendo.2012.00133; PMCID=PMC3499787; RA Saiselet, Manuel RA Floor, Sebastien RA Tarabichi, Maxime RA Dom, Genevieve RA Hebrant, Aline RA van Staveren, Wilma C.G. RA Maenhaut, Carine RT "Thyroid cancer cell lines: an overview."; RL Front. Endocrinol. 3:133.1-133.9(2012). // RX PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280; RA Landa, Inigo RA Pozdeyev, Nikita RA Korch, Christopher T. RA Marlow, Laura A. RA Smallridge, Robert Christian RA Copland, John Alton 3rd RA Henderson, Ying C. RA Lai, Stephen Y. RA Clayman, Gary L. RA Onoda, Naoyoshi RA Tan, Aik-Choon RA Garcia-Rendueles, Maria E.R. RA Knauf, Jeffrey A. RA Haugen, Bryan R. RA Fagin, James Alexander RA Schweppe, Rebecca E. RT "Comprehensive genetic characterization of human thyroid cancer cell RT lines: a validated panel for preclinical studies."; RL Clin. Cancer Res. 25:3141-3151(2019). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026; RA van Staveren, Wilma C.G. RA Weiss-Solis, David Y. RA Delys, Laurent RA Duprez, Laurence RA Andry, Guy RA Franc, Brigitte RA Thomas, Gerry RA Libert, Frederick RA Dumont, Jacques-Emile RA Detours, Vincent RA Maenhaut, Carine RT "Human thyroid tumor cell lines derived from different tumor types RT present a common dedifferentiated phenotype."; RL Cancer Res. 67:8113-8120(2007). // RX PubMed=19087340; DOI=10.1186/1471-2407-8-371; PMCID=PMC2651892; RA Ribeiro, Franclim Ricardo RA Meireles, Ana Margarida RA Rocha, Ana Sofia RA Teixeira, Manuel R. RT "Conventional and molecular cytogenetics of human non-medullary RT thyroid carcinoma: characterization of eight cell line models and RT review of the literature on clinical samples."; RL BMC Cancer 8:371.1-371.11(2008). // RX PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785; RA Yu, Katharine RA Chen, Bin RA Aran, Dvir RA Charalel, Joe RA Yau, Christina RA Wolf, Douglas M. RA van 't Veer, Laura J. RA Butte, Atul Janardhan RA Goldstein, Ted RA Sirota, Marina RT "Comprehensive transcriptomic analysis of cell lines as models of RT primary tumors across 22 tumor types."; RL Nat. Commun. 10:3574.1-3574.11(2019). // RX PubMed=1297527; RA Paulin, Christian RA Fabien, Nicole RA Fusco, Alfredo RA Pages, Marie-Pierre RA Patricot, Marie-Claude RA Bornet, Hubert RA Dubois, Paul-Marie RT "Description of a cell line established from a human thyroid papillary RT carcinoma and synthesizing human chorionic gonadotropin hormone."; RL C. R. Acad. Sci. III, Sci. Vie 315:493-498(1992). // RX PubMed=15172756; DOI=10.1016/j.cancergencyto.2003.09.023; RA Dettori, Tinuccia RA Frau, Daniela Virginia RA Garcia, Juan L. RA Pierantoni, Giovanna Maria RA Lee, Charles RA Hernandez-Rivas, Jesus Maria RA Fusco, Alfredo RA Morton, Cynthia Casson RA Vanni, Roberta RT "Comprehensive conventional and molecular cytogenetic characterization RT of B-CPAP, a human papillary thyroid carcinoma-derived cell line."; RL Cancer Genet. Cytogenet. 151:171-177(2004). // RX PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569; RA Schweppe, Rebecca E. RA Klopper, Joshua Paul RA Korch, Christopher T. RA Pugazhenthi, Umarani RA Benezra, Miriam RA Knauf, Jeffrey A. RA Fagin, James Alexander RA Marlow, Laura A. RA Copland, John Alton 3rd RA Smallridge, Robert Christian RA Haugen, Bryan R. RT "Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer RT cell lines reveals cross-contamination resulting in cell line RT redundancy and misidentification."; RL J. Clin. Endocrinol. Metab. 93:4331-4341(2008). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=8156527; DOI=10.1002/1097-0142(19940415)73:8<2206::AID-CNCR2820730828>3.0.CO;2-M; RA Fabien, Nicole RA Fusco, Alfredo RA Santoro, Massimo Mattia RA Barbier, Yves RA Dubois, Paul-Marie RA Paulin, Christian RT "Description of a human papillary thyroid carcinoma cell line. RT Morphologic study and expression of tumoral markers."; RL Cancer 73:2206-2212(1994). // RX PubMed=14522906; RA Frasca, Francesco RA Vella, Veronica RA Aloisi, Alessandra RA Mandarino, Angelo RA Mazzon, Emanuela RA Vigneri, Riccardo RA Vigneri, Paolo RT "p73 tumor-suppressor activity is impaired in human thyroid cancer."; RL Cancer Res. 63:5829-5837(2003). // RX PubMed=17725429; DOI=10.1089/thy.2007.0097; RA Meireles, Ana Margarida RA Preto, Ana RA Rocha, Ana Sofia RA Rebocho, Ana Paula RA Maximo, Valdemar RA Pereira-Castro, Isabel RA Moreira, Severina RA Feijao, Talia RA Botelho, Tiago RA Marques, Ricardo RA Trovisco, Vitor RA Cirnes, Luis RA Alves, Cintia RA Velho, Sergia RA Soares, Paula RA Sobrinho-Simoes, Manuel RT "Molecular and genotypic characterization of human thyroid follicular RT cell carcinoma-derived cell lines."; RL Thyroid 17:707-715(2007). // RX PubMed=28775782; DOI=10.7150/jca.18855; PMCID=PMC5535718; RA Caria, Paola RA Pillai, Rita RA Dettori, Tinuccia RA Frau, Daniela Virginia RA Zavattari, Patrizia RA Riva, Gabriele RA Romano, Gabriele RA Pani, Fabiana RA Bentivegna, Angela RA Giovannoni, Roberto RA Pagni, Fabio RA Sogos, Valeria RA Vanni, Roberta RT "Thyrospheres from B-CPAP cell line with BRAF and TERT promoter RT mutations have different functional and molecular features than RT parental cells."; RL J. Cancer 8:1629-1639(2017). //