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Cellosaurus ACH-2 (CVCL_0138)

[Text version]
Cell line name ACH-2
Synonyms ACH2
Accession CVCL_0138
Resource Identification Initiative To cite this cell line use: ACH-2 (RRID:CVCL_0138)
Comments Population: Caucasian.
Virology: Latently infected with HIV-1 isolate LAI. The main site of integration of the HIV-1 genome is located in the NT5C3A gene. Additional integration sites are found in the SLC25A25-AS, EPT1 and NPLOC4 genes (PubMed=26912621; PubMed=28086908).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6244 (CEM A3.01)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=2463307; DOI=10.4049/jimmunol.142.2.431
Kathleen A. Clouse, Douglas Powell, Ivora Washington, Guido Poli, Klaus Strebel, William L. Farrar, Paul Barstad, Joseph Kovacs, Anthony Stephen Fauci, Thomas M. Folks;
Monokine regulation of human immunodeficiency virus-1 expression in a chronically infected human T cell clone.
J. Immunol. 142:431-438(1989)

PubMed=26912621; DOI=10.1128/JVI.01617-15; PMCID=PMC4836361
Sara Sunshine, Rory Kirchner, Sami Samir Amr, Leandra Mansur, Rimma Shakhbatyan, Michelle Kim, Alberto Bosque, Robert Francis Siliciano, Vicente Planelles, Oliver Hofmann, Shannan Ho Sui, Jonathan Z. Li;
HIV integration site analysis of cellular models of HIV latency with a probe-enriched next-generation sequencing assay.
J. Virol. 90:4511-4519(2016)

PubMed=28086908; DOI=10.1186/s12977-016-0325-2; PMCID=PMC5237276
Jori Symons, Abha Chopra, Eva Malatinkova, Ward De Spiegelaere, Shay Leary, Don Cooper, Chike O. Abana, Ajantha Rhodes, Simin D. Rezaei, Linos Vandekerckhove, Simon Mallal ...Show all 13 authors... , Sharon Ruth Lewin, Paul Urquhart Cameron; Show fewer authors
HIV integration sites in latently infected cell lines: evidence of ongoing replication.
Retrovirology 14:2.1-2.11(2017)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-349
Cell line databases/resources MCCL; MCC:0000031
cancercelllines; CVCL_0138
Anatomy/cell type resources BTO; BTO_0002551
Chemistry resources ChEMBL-Cells; CHEMBL3307897
ChEMBL-Targets; CHEMBL614263
PubChem_Cell_line; CVCL_0138
Encyclopedic resources Wikidata; Q54608362
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number17