ID   ACH-2
AC   CVCL_0138
SY   ACH2
DR   BTO; BTO:0002551
DR   MCCL; MCC:0000031
DR   cancercelllines; CVCL_0138
DR   ChEMBL-Cells; CHEMBL3307897
DR   ChEMBL-Targets; CHEMBL614263
DR   HIVReagentProgram; ARP-349
DR   PubChem_Cell_line; CVCL_0138
DR   Wikidata; Q54608362
RX   PubMed=2463307;
RX   PubMed=26912621;
RX   PubMed=28086908;
CC   Population: Caucasian.
CC   Virology: Latently infected with HIV-1 isolate LAI. The main site of integration of the HIV-1 genome is located in the NT5C3A gene. Additional integration sites are found in the SLC25A25-AS, EPT1 and NPLOC4 genes (PubMed=26912621; PubMed=28086908).
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6244 ! CEM A3.01
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 15
//
RX   PubMed=2463307; DOI=10.4049/jimmunol.142.2.431;
RA   Clouse K.A., Powell D., Washington I., Poli G., Strebel K., Farrar W.L.,
RA   Barstad P., Kovacs J., Fauci A.S., Folks T.M.;
RT   "Monokine regulation of human immunodeficiency virus-1 expression in a
RT   chronically infected human T cell clone.";
RL   J. Immunol. 142:431-438(1989).
//
RX   PubMed=26912621; DOI=10.1128/JVI.01617-15;
RA   Sunshine S., Kirchner R., Amr S.S., Mansur L., Shakhbatyan R., Kim M.,
RA   Bosque A., Siliciano R.F., Planelles V., Hofmann O., Sui S.H.,
RA   Li J.Z.;
RT   "HIV integration site analysis of cellular models of HIV latency with
RT   a probe-enriched next-generation sequencing assay.";
RL   J. Virol. 90:4511-4519(2016).
//
RX   PubMed=28086908; DOI=10.1186/s12977-016-0325-2;
RA   Symons J., Chopra A., Malatinkova E., De Spiegelaere W., Leary S.,
RA   Cooper D., Abana C.O., Rhodes A., Rezaei S.D., Vandekerckhove L.,
RA   Mallal S., Lewin S.R., Cameron P.U.;
RT   "HIV integration sites in latently infected cell lines: evidence of
RT   ongoing replication.";
RL   Retrovirology 14:2.1-2.11(2017).
//