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Cellosaurus A375.S2 (CVCL_0136)

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Cell line name A375.S2
Synonyms A-375.S2; A375-S2; A375S2; A375s2
Accession CVCL_0136
Resource Identification Initiative To cite this cell line use: A375.S2 (RRID:CVCL_0136)
Comments Population: Caucasian.
Omics: Variations; SNP array analysis.
Miscellaneous: Not sure what is the relationship between A375.S2 and A375S1.
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1872

Markers:
AmelogeninX
CSF1PO11,12
D5S81812
D7S8209
D13S31711,14
D16S5399
TH018
TPOX8,10
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-1872 - Discontinued
BCRC; 60263
Cell line databases/resources CLO; CLO_0001583
MCCL; MCC:0000029
cancercelllines; CVCL_0136
LINCS_HMS; 50003
LINCS_LDP; LCL-1231
Anatomy/cell type resources BTO; BTO_0005815
Encyclopedic resources Wikidata; Q54606870
Gene expression databases GEO; GSM827493
Polymorphism and mutation databases Progenetix; CVCL_0136
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29