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Cellosaurus A375.S2 (CVCL_0136)

[Text version]
Cell line name A375.S2
Synonyms A-375.S2; A375-S2; A375S2; A375s2
Accession CVCL_0136
Resource Identification Initiative To cite this cell line use: A375.S2 (RRID:CVCL_0136)
Comments Population: Caucasian.
Omics: SNP array analysis.
Miscellaneous: Not sure what is the relationship between A375.S2 and A375S1.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO11,12
D5S81812
D7S8209
D13S31711,14
D16S5399
TH018
TPOX8,10
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-1872
BCRC; 60263
Cell line databases/resources CLO; CLO_0001583
MCCL; MCC:0000029
cancercelllines; CVCL_0136
LINCS_HMS; 50003
LINCS_LDP; LCL-1231
Anatomy/cell type resources BTO; BTO:0005815
Encyclopedic resources Wikidata; Q54606870
Gene expression databases GEO; GSM827493
Polymorphism and mutation databases Progenetix; CVCL_0136
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number25