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Cellosaurus 435.eB (CVCL_0124)

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Cell line name 435.eB
Accession CVCL_0124
Resource Identification Initiative To cite this cell line use: 435.eB (RRID:CVCL_0124)
Comments Problematic cell line: Contaminated. Parent cell line (MDA-MB-435) has been shown to be a M14 derivative.
Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3430; ERBB2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0417 (MDA-MB-435)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
Publications

PubMed=9067293
Ming Tan, Jun Yao, Di-Hua Yu;
Overexpression of the c-erbB-2 gene enhanced intrinsic metastasis potential in human breast cancer cells without increasing their transformation abilities.
Cancer Res. 57:1199-1205(1997)

Cross-references
Cell line databases/resources MCCL; MCC:0000016
cancercelllines; CVCL_0124
Encyclopedic resources Wikidata; Q54603035
Entry history
Entry creation04-Apr-2012
Last entry update27-Nov-2025
Version number27