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Cellosaurus SK-MEL-2 (CVCL_0069)

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Cell line name SK-MEL-2
Synonyms SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2
Accession CVCL_0069
Resource Identification Initiative To cite this cell line use: SK-MEL-2 (RRID:CVCL_0069)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Part of: NCI-60 cancer cell line panel.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 779.
Population: Caucasian.
Doubling time: 32 hours (PubMed=7718330); >50 hours (PubMed=8631022); 45.5 hours (NCI-DTP=SK-MEL-2); ~56 hours (PBCF).
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Metabolomics.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; Fluorescent probe library screening.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; lncRNA profiling; RT-qPCR platform.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Misspelling: SKm12; Note=Occasionally.
Derived from site: Metastatic; Thigh, skin; UBERON=UBERON_0004262.
Sequence variations
HLA typing Source: PubMed=15748285
Class I
HLA-AA*03,26
HLA-BB*35,38
HLA-CC*04,12:03:01
Class II
HLA-DPDPB1*02:01:02,04:01
HLA-DQDQB1*03:01:01,06:03
HLA-DRDRB1*04:02,13:01:01

Source: PubMed=26589293
Class I
HLA-AA*03:01,26:01
HLA-BB*35:08,38:01
HLA-CC*04:01,12:03
Class II
HLA-DQDQA1*03:02,03:02
DQB1*06:11,06:11
HLA-DRDRB1*04:02,13:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.43
Native American0
East Asian, North2.36
East Asian, South1.87
South Asian7.21
European, North28.23
European, South58.89
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_J266 (SK-MEL-2-Luc)
Sex of cell Male
Age at sampling 60Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-68; Cosmic-CLP=905955; PubMed=19372543; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133821,24
D3S135814,16
D5S81811,12,13 (ATCC=HTB-68)
12,13 (Cosmic-CLP=905955; PubMed=19372543; PubMed=25877200)
D7S82011,12
D8S117911,12,13 (ATCC=HTB-68)
12,13 (PubMed=19372543)
D13S31711
D16S5398,9
D18S5115,16
D19S43312,13,15 (ATCC=HTB-68)
12,15 (PubMed=19372543)
D21S1129,30
FGA19,25
Penta D10,15
Penta E7,16
TH019
TPOX8,9
vWA16,17 (ATCC=HTB-68)
17 (Cosmic-CLP=905955; PubMed=19372543; PubMed=25877200)

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; NCI DTP; NCI-60; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=45
Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544462
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/melanoma-xenograft/sk-mel-2-xenograft-model/
Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-melanoma-cell-line-sk-mel-2
Publications

DOI=10.1007/978-1-4757-1647-4_5
Jorgen Fogh, Germain L. Trempe;
New human tumor cell lines.
(In book chapter) Human tumor cells in vitro; Fogh, Jorgen (eds.); pp.115-159; Springer; New York; USA (1975)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

DOI=10.1007/BF00199208
Josef Bruggen, Clemens Sorg, Egon Macher;
Membrane associated antigens of human malignant melanoma V: Serological typing of cell lines using antisera from nonhuman primates.
Cancer Immunol. Immunother. 5:53-62(1978)

PubMed=6220172
Nicholas C. Dracopoli, Jorgen Fogh;
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=2784858; DOI=10.1073/pnas.86.8.2804; PMCID=PMC287007
Alexander Knuth, Thomas Wolfel, Eva Klehmann-Hieb, Thierry Boon, Karl-Hermann Meyer zum Buschenfelde;
Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection.
Proc. Natl. Acad. Sci. U.S.A. 86:2804-2808(1989)

PubMed=2041050; DOI=10.1093/jnci/83.11.757
Anne Monks, Dominic A. Scudiero, Philip Skehan, Robert H. Shoemaker, Kenneth D. Paull, David T. Vistica, Curtis D. Hose, John Langley, Paul Cronise, Anne Vaigro-Wolff, Marcia Gray-Goodrich ...Show all 14 authors... , Hugh Campbell, Joseph G. Mayo, Michael R. Boyd; Show fewer authors
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
J. Natl. Cancer Inst. 83:757-766(1991)

PubMed=7999427; DOI=10.1016/0959-8049(94)90188-0
Elaine S. Marshall, John H.L. Matthews, James H.F. Shaw, Johanna Nixon, Paul Tumewu, Graeme John Finlay, Karen M. Holdaway, Bruce Charles Baguley;
Radiosensitivity of new and established human melanoma cell lines: comparison of [3H]thymidine incorporation and soft agar clonogenic assays.
Eur. J. Cancer 30A:1370-1376(1994)

PubMed=7718330; DOI=10.1016/0959-8049(94)00472-H
Bruce Charles Baguley, Elaine S. Marshall, John Richard Whittaker, M.C. Dotchin, Johanna Nixon, Michael R. McCrystal, Graeme John Finlay, John H.L. Matthews, Karen M. Holdaway, Pierre Leonardus van Zijl;
Resistance mechanisms determining the in vitro sensitivity to paclitaxel of tumour cells cultured from patients with ovarian cancer.
Eur. J. Cancer 31A:230-237(1995)

PubMed=8631022
Insoo Bae, Martin L. Smith, M. Saeed Sheikh, Qi-Min Zhan, Dominic A. Scudiero, Stephen H. Friend, Patrick M. O'Connor, Albert J. Fornace Jr.;
An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines.
Cancer Res. 56:840-847(1996)

PubMed=8755562; DOI=10.1073/pnas.93.15.7832; PMCID=PMC38834
Da-Cai Liu, Eric Pearlman, Eugenia Diaconu, Kun Guo, Hiroshi Mori, Tariq Haqqi, Sanford David Markowitz, James K.V. Willson, Man-Sun Sy;
Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.
Proc. Natl. Acad. Sci. U.S.A. 93:7832-7837(1996)

PubMed=9331090
Patrick M. O'Connor, Joany Jackman, Insoo Bae, Timothy Gene Myers, Sai-Jun Fan, Masato Mutoh, Dominic A. Scudiero, Anne Monks, Edward A. Sausville, John N. Weinstein, Stephen H. Friend ...Show all 13 authors... , Albert J. Fornace Jr., Kurt W. Kohn; Show fewer authors
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.
Cancer Res. 57:4285-4300(1997)

PubMed=10700174; DOI=10.1038/73432
Douglas T. Ross, Uwe Scherf, Michael Bruce Eisen, Charles M. Perou, Christian Rees, Paul T. Spellman, Vishwanath R. Iyer, Stefanie S. Jeffrey, Matt van de Rijn, Mark C. Waltham, Alexander Pergamenschikov ...Show all 18 authors... , Jeffrey C.F. Lee, Deval Lashkari, Dari Shalon, Timothy Gene Myers, John N. Weinstein, David Botstein, Patrick O'Reilly Brown; Show fewer authors
Systematic variation in gene expression patterns in human cancer cell lines.
Nat. Genet. 24:227-235(2000)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=14871852; DOI=10.1158/0008-5472.CAN-03-2209
Kevin T. Hogan, Michael A. Coppola, Christine L. Gatlin, Lee W. Thompson, Jeffrey Shabanowitz, Donald Frederick Hunt, Victor H. Engelhard, Mark M. Ross, Craig L. Slingluff Jr.;
Identification of novel and widely expressed cancer/testis gene isoforms that elicit spontaneous cytotoxic T-lymphocyte reactivity to melanoma.
Cancer Res. 64:1157-1163(2004)

PubMed=15467732; DOI=10.1038/sj.onc.1208152
Hideaki Tanami, Issei Imoto, Akira Hirasawa, Yasuhiro Yuki, Itaru Sonoda, Jun Inoue, Kohichiroh Yasui, Akiko Misawa-Furihata, Yutaka Kawakami, Johji Inazawa;
Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.
Oncogene 23:8796-8804(2004)

PubMed=15748285; DOI=10.1186/1479-5876-3-11; PMCID=PMC555742
Sharon Adams, Fu-Meei Robbins, Deborah Chen, Devika Wagage, Susan L. Holbeck, Herbert Carpenter Morse 3rd, David Stroncek, Francesco M. Marincola;
HLA class I and II genotype of the NCI-60 cell lines.
J. Transl. Med. 3:11.1-11.8(2005)

PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433; PMCID=PMC2705832
Ogechi N. Ikediobi, Helen R. Davies, Graham Robert Bignell, Sarah Edkins, Claire Stevens, Sarah O'Meara, Thomas Santarius, Tim Avis, Syd Barthorpe, Lisa Brackenbury, Gemma Buck ...Show all 49 authors... , Adam P. Butler, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathan Hinton, Chris Hunter, Andy Jenkinson, David Jones, Vivian Kosmidou, Richard Lugg, Andrew Menzies, Tatiana Mironenko, Adrian Parker, Janet Perry, Keiran Martin Raine, David Richardson, Rebecca Shepherd, Alex Small, Raffaella Smith, Helen Solomon, Philip J. Stephens, Jon W. Teague, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, William C. Reinhold, John N. Weinstein, Michael Rudolf Stratton, P. Andrew Futreal, Richard Wooster; Show fewer authors
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
Mol. Cancer Ther. 5:2606-2612(2006)

PubMed=18277095; DOI=10.4161/cbt.7.5.5712
Hanna Berglind, Yudi Pawitan, Shunsuke Kato, Chikashi Ishioka, Thierry Soussi;
Analysis of p53 mutation status in human cancer cell lines: a paradigm for cell line cross-contamination.
Cancer Biol. Ther. 7:699-708(2008)

PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921; PMCID=PMC4020356
Philip L. Lorenzi, William C. Reinhold, Sudhir Varma, Amy A. Hutchinson, Yves Pommier, Stephen Jacob Chanock, John N. Weinstein;
DNA fingerprinting of the NCI-60 cell line panel.
Mol. Cancer Ther. 8:713-724(2009)

PubMed=19727395; DOI=10.1371/journal.pone.0006888; PMCID=PMC2731225
Raymond Couric Wadlow, Ben S. Wittner, S. Aidan Finley, Henry Bergquist, Rabi Upadhyay, Stephen P. Finn, Massimo Loda, Umar Mahmood, Sridhar Ramaswamy;
Systems-level modeling of cancer-fibroblast interaction.
PLoS ONE 4:e6888.1-e6888.10(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22068913; DOI=10.1073/pnas.1111840108; PMCID=PMC3219108
Jean-Pierre Gillet, Anna Maria Calcagno, Sudhir Varma, Miguel Marino, Lisa J. Green, Meena I. Vora, Chirayu Patel, Josiah N. Orina, Tatiana A. Eliseeva, Vineet Singal, Raji Padmanabhan ...Show all 17 authors... , Ben Davidson, Ram Ganapathi, Anil K. Sood, Bo R. Rueda, Suresh V. Ambudkar, Michael Marc Gottesman; Show fewer authors
Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance.
Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011)

PubMed=21725359; DOI=10.1038/onc.2011.250; PMCID=PMC3267014
Feng Xing, Yogindra Persaud, Christine A. Pratilas, Barry Stephen Taylor, Manickam Janakiraman, Qing-Bai She, Humilidad F. Gallardo, C. Liu, Taha Merghoub, Blake E. Hefter, Igor Dolgalev ...Show all 19 authors... , Agnes J. Viale, Adriana Heguy, Elisa de Stanchina, David Cobrinik, Gideon Bollag, Jedd D. Wolchok, Alan N. Houghton, David B. Solit; Show fewer authors
Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF.
Oncogene 31:446-457(2012)

PubMed=21912889; DOI=10.1007/s10637-011-9744-z
Hamish S. Sutherland, In Young Hwang, Elaine S. Marshall, Brent S. Lindsay, William Alexander Denny, Catherine Gilchrist, Wayne R. Joseph, Debra Greenhalgh, Emma Richardson, Philip Kestell, Angela Ding, Bruce Charles Baguley;
Therapeutic reactivation of mutant p53 protein by quinazoline derivatives.
Invest. New Drugs 30:2035-2045(2012)

PubMed=22347499; DOI=10.1371/journal.pone.0031628; PMCID=PMC3276511
Xiao-Yang Ruan, Jean-Pierre A. Kocher, Yves Pommier, Hong-Fang Liu, William C. Reinhold;
Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap trios, and relation to fragile site location.
PLoS ONE 7:e31628.1-e31628.9(2012)

PubMed=22384151; DOI=10.1371/journal.pone.0032096; PMCID=PMC3285665
Jun-Seok Lee, Yun Kyung Kim, Han Jo Kim, Siti Hajar, Yee Ling Tan, Nam-Young Kang, Shin Hui Ng, Chang No Yoon, Young-Tae Chang;
Identification of cancer cell-line origins using fluorescence image-based phenomic screening.
PLoS ONE 7:e32096.1-e32096.8(2012)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22628656; DOI=10.1126/science.1218595; PMCID=PMC3526189
Mohit Jain, Roland Nilsson, Sonia Sharma, Nikhil Madhusudhan, Toshimori Kitami, Amanda L. Souza, Ran Kafri, Marc Wallace Kirschner, Clary B. Clish, Vamsi Krishna Mootha;
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.
Science 336:1040-1044(2012)

PubMed=23285177; DOI=10.1371/journal.pone.0052760; PMCID=PMC3532357
Adam B. Schayowitz, Greg P. Bertenshaw, Emiko Jeffries, Timothy Schatz, James Cotton, Jessie Villanueva, Meenhard Herlyn, Clemens Krepler, Adina Vultur, Wei Xu, Gordon H. Yu ...Show all 13 authors... , Lynn Mara Schuchter, Douglas P. Clark; Show fewer authors
Functional profiling of live melanoma samples using a novel automated platform.
PLoS ONE 7:e52760.1-e52760.8(2012)

PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342; PMCID=PMC4893961
Ogan Demir Abaan, Eric C. Polley, Sean R. Davis, Yue-Lin J. Zhu, Sven Bilke, Robert L. Walker, Marbin A. Pineda, Yevgeniy Gindin, Yuan Jiang, William C. Reinhold, Susan L. Holbeck ...Show all 15 authors... , Richard M. Simon, James H. Doroshow, Yves Pommier, Paul S. Meltzer; Show fewer authors
The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.
Cancer Res. 73:4372-4382(2013)

PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018
Amin Moghaddas Gholami, Hannes Hahne, Zhi-Xiang Wu, Florian Johann Auer, Chen Meng, Mathias Wilhelm, Bernhard Kuster;
Global proteome analysis of the NCI-60 cell line panel.
Cell Rep. 4:609-620(2013)

PubMed=24279929; DOI=10.1186/2049-3002-1-20; PMCID=PMC4178206
Sonia C. Dolfi, Leo Li-Ying Chan, Jean Qiu, Philip M. Tedeschi, Joseph Rocco Bertino, Kim Marie Hirshfield, Zoltan Nagy Oltvai, Alexei Vazquez;
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates.
Cancer Metab. 1:20.1-20.13(2013)

PubMed=24576830; DOI=10.1158/0008-5472.CAN-13-2625; PMCID=PMC4005042
Moriah Heller Nissan, Christine A. Pratilas, Alexis M. Jones, Ricardo Ramirez, Helen Won, Cai-Lian Liu, Shakuntala Tiwari, Li Kong, Aphrothiti J. Hanrahan, Zhan Yao, Taha Merghoub ...Show all 19 authors... , Antoni Ribas, Paul B. Chapman, Rona D. Yaeger, Barry Stephen Taylor, Nikolaus Schultz, Michael F. Berger, Neal Rosen, David B. Solit; Show fewer authors
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Cancer Res. 74:2340-2350(2014)

PubMed=24670534; DOI=10.1371/journal.pone.0092047; PMCID=PMC3966786
Sudhir Varma, Yves Pommier, Margot Sunshine, John N. Weinstein, William C. Reinhold;
High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner.
PLoS ONE 9:e92047.1-e92047.15(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25728708; DOI=10.1111/pcmr.12364
Celia J. Vogel, Marjon A. Smit, Gianluca Maddalo, Patricia Abrao Possik, Rolf W. Sparidans, Sjoerd H. van der Burg, Elizabeth M.E. Verdegaal, Albert J.R. Heck, Ahmed A. Samatar, Jos Heindrik Beijnen, A.F. Maarten Altelaar, Daniel S. Peeper;
Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.
Pigment Cell Melanoma Res. 28:307-317(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27377824; DOI=10.1038/sdata.2016.52; PMCID=PMC4932877
Pieter Mestdagh, Steve Lefever, Pieter-Jan Volders, Stefaan Derveaux, Jan Hellemans, Jo Vandesompele;
Long non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR.
Sci. Data 3:160052.1-160052.6(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27533468; DOI=10.1080/15384101.2016.1208862; PMCID=PMC5026796
Helene Malka-Mahieu, Isabelle Girault, Margot Rubington, Melissa Leriche, Caroline Welsch, Nyam Kamsu-Kom, Qian Zhao, Laurent Desaubry, Stephan Vagner, Caroline Robert;
Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines.
Cell Cycle 15:2405-2409(2016)

PubMed=27807467; DOI=10.1186/s13100-016-0078-4; PMCID=PMC5087121
John G. Zampella, Nemanja Rodic, Wan Rou Yang, Cheng Ran Lisa Huang, Jane Welch, Veena P. Gnanakkan, Toby Charles Cornish, Jef D. Boeke, Kathleen H. Burns;
A map of mobile DNA insertions in the NCI-60 human cancer cell panel.
Mob. DNA 7:20.1-20.11(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=38861359; DOI=10.1158/0008-5472.CAN-23-3031; PMCID=PMC11292194
Mark W. Kunkel, Nathan P. Coussens, Joel Morris, Ronald C. Taylor, Thomas S. Dexheimer, Eric M. Jones, James H. Doroshow, Beverly A. Teicher;
HTS384 NCI60: the next phase of the NCI60 screen.
Cancer Res. 84:2403-2416(2024)

Cross-references
Cell line collections (Providers) ATCC; HTB-68
CancerTools; 161915
CLS; 300423
KCLB; 30068
NCI-DTP; SK-MEL-2
Cell line databases/resources CLO; CLO_0009041
cancercelllines; CVCL_0069
Cell_Model_Passport; SIDM00082
CGH-DB; 9322-4
Cosmic-CLP; 905955
DepMap; ACH-001190
LINCS_LDP; LCL-1256
SKY/M-FISH/CGH; 2820
Anatomy/cell type resources BTO; BTO_0003476
Biological sample resources BioSample; SAMN03471882
BioSample; SAMN03472752
BioSample; SAMN05292464
BioSample; SAMN10988256
CRISP screens repositories BioGRID_ORCS_Cell_line; 1012
Chemistry resources ChEMBL-Cells; CHEMBL3307743
ChEMBL-Targets; CHEMBL614917
GDSC; 905955
PharmacoDB; SKMEL2_1394_2019
PubChem_Cell_line; CVCL_0069
Encyclopedic resources Wikidata; Q54953905
Experimental variables resources EFO; EFO_0002079
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM2109
GEO; GSM50204
GEO; GSM50266
GEO; GSM188225
GEO; GSM188255
GEO; GSM188314
GEO; GSM743467
GEO; GSM750824
GEO; GSM799356
GEO; GSM799419
GEO; GSM844688
GEO; GSM844689
GEO; GSM847115
GEO; GSM887585
GEO; GSM888668
GEO; GSM1153426
GEO; GSM1181281
GEO; GSM1181359
GEO; GSM1670437
GEO; GSM1671997
GEO; GSM1672003
GEO; GSM1672044
GEO; GSM1672075
GEO; GSM1672083
GEO; GSM1672088
GEO; GSM1672104
GEO; GSM1672117
GEO; GSM1672126
GEO; GSM2124650
Polymorphism and mutation databases Cosmic; 724824
Cosmic; 875885
Cosmic; 897468
Cosmic; 905235
Cosmic; 905955
Cosmic; 974073
Cosmic; 974257
Cosmic; 1006555
Cosmic; 1022288
Cosmic; 1044266
Cosmic; 1045411
Cosmic; 1067222
Cosmic; 1092632
Cosmic; 1132585
Cosmic; 1155283
Cosmic; 1175871
Cosmic; 1303053
Cosmic; 1305367
Cosmic; 1458964
Cosmic; 1459662
Cosmic; 1477419
Cosmic; 1669129
Cosmic; 1995633
Cosmic; 1998475
Cosmic; 2159450
Cosmic; 2479250
IARC_TP53; 18086
Progenetix; CVCL_0069
Proteomic databases PRIDE; PXD005942
PRIDE; PXD005946
PRIDE; PXD030206
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number48