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Cellosaurus D341 Med (CVCL_0018)

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Cell line name D341 Med
Synonyms D-341 Med; D-341 MED; D-341 Med-C; D-341Med; D-341MED; D341_Med; D341Med; D341MED; D341MD; D-341; D341; Med 341; H341
Accession CVCL_0018
Resource Identification Initiative To cite this cell line use: D341 Med (RRID:CVCL_0018)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: ENCODE project common cell types; tier 3.
Population: Caucasian.
Doubling time: 37 hours (ATCC=HTB-187).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Omics: Transcriptome analysis by serial analysis of gene expression (SAGE).
Miscellaneous: The values for the STR markers F13A01, F13B, FESFPS and LPL used to be shown on the ATCC website but are no longer displayed (see Internet archive link for archival version).
Derived from site: In situ; Brain, cerebellum; UBERON=UBERON_0002037.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North1.21
East Asian, South0
South Asian0.49
European, North68.21
European, South30.09
Disease Medulloblastoma, non-WNT/non-SHH, group 3 (NCIt: C129445)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 3Y5M
Category Cancer cell line
STR profile Source(s): ATCC; CCRID

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133817
D3S135816,18
D5S81811,12
D7S8209,13
D8S117914
D13S31711,13
D16S53912,14
D18S5112,17
D19S43313
D21S1130,31
F13A016,7
F13B8,10
FESFPS10,13
FGA19,23
LPL11
TH016,9.3
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Web pages http://genome.ucsc.edu/ENCODE/protocols/cell/human/MedulloD341_Crawford_protocol.pdf
https://web.archive.org/web/20160611152450/http://www.atcc.org:80/products/all/HTB-187.aspx#specifications
Publications

PubMed=3279793
Friedman H.S., Burger P.C., Bigner S.H., Trojanowski J.Q., Brodeur G.M., He X.-M., Wikstrand C.J., Kurtzberg J., Berens M.E., Halperin E.C., Bigner D.D.
Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc.
Am. J. Pathol. 130:472-484(1988)

PubMed=2180567
Bigner S.H., Friedman H.S., Vogelstein B., Oakes W.J., Bigner D.D.
Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.
Cancer Res. 50:2347-2350(1990)

PubMed=1822845
Wikstrand C.J., Friedman H.S., Bigner D.D.
Medulloblastoma cell-substrate interaction in vitro.
Invasion Metastasis 11:310-324(1991)

PubMed=8275086; DOI=10.1038/ng1193-230
Galili N., Davis R.J., Fredericks W.J., Mukhopadhyay S., Rauscher F.J. III, Emanuel B.S., Rovera G., Barr F.G.
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
Nat. Genet. 5:230-235(1993)

DOI=10.1007/0-306-46861-1_11
Ali-Osman F.
Brain tumors.
(In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York (1999)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20847082; DOI=10.1093/neuonc/noq091
Teider N., Scott D.K., Neiss A., Weeraratne S.D., Amani V.M., Wang Y.-F., Marquez V.E., Cho Y.-J., Pomeroy S.L.
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Neuro-oncol. 12:1244-1256(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.
In vitro models of medulloblastoma: choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004
Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31963405; DOI=10.3390/cancers12010226
Casciati A., Tanori M., Manczak R., Saada S., Tanno B., Giardullo P., Porcu E., Rampazzo E., Persano L., Viola G., Dalmay C., Lalloue F., Pothier A., Merla C., Mancuso M.
Human medulloblastoma cell lines: investigating on cancer stem cell-like phenotype.
Cancers (Basel) 12:226.1-226.14(2020)

Cross-references
Cell line collections (Providers) ATCC; HTB-187
CLS; 305136
KCB; KCB 2010239YJ
Cell line databases/resources CLO; CLO_0002677
cancercelllines; CVCL_0018
CCRID; 1101HUM-PUMC000102
Cell_Model_Passport; SIDM01492
DepMap; ACH-000095
IGRhCellID; D341Med
Biological sample resources BioSample; SAMN03472737
BioSample; SAMN10988120
ENCODE; ENCBS254AAA
CRISP screens repositories BioGRID_ORCS_Cell_line; 689
Chemistry resources ChEMBL-Cells; CHEMBL3308450
ChEMBL-Targets; CHEMBL614478
PharmacoDB; D341Med_280_2019
PubChem_Cell_line; CVCL_0018
Encyclopedic resources Wikidata; Q54817217
Experimental variables resources EFO; EFO_0002157
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2770
GEO; GSM383763
GEO; GSM482333
GEO; GSM827339
GEO; GSM886970
GEO; GSM888039
GEO; GSM918117
GEO; GSM919358
GEO; GSM1008577
Polymorphism and mutation databases Cosmic; 923657
Cosmic; 973263
Cosmic; 974282
Cosmic; 975025
Cosmic; 1097759
Cosmic; 2362652
Cosmic; 2731178
Cosmic; 2772984
IARC_TP53; 30029
LiGeA; CCLE_586
Progenetix; CVCL_0018
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number36