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Cellosaurus D341 Med (CVCL_0018)

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Cell line name D341 Med
Synonyms D-341 Med; D-341 MED; D-341 Med-C; D-341Med; D-341MED; D341_Med; D341Med; D341MED; D341MD; D-341; D341; Med 341; H341
Accession CVCL_0018
Resource Identification Initiative To cite this cell line use: D341 Med (RRID:CVCL_0018)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: ENCODE project common cell types; tier 3.
Population: Caucasian.
Doubling time: 37 hours (ATCC=HTB-187).
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Transcriptomics; Serial analysis of gene expression (SAGE).
Omics: Variations; SNP array analysis.
Miscellaneous: The values for the STR markers F13A01, F13B, FESFPS and LPL used to be shown on the ATCC website but are no longer displayed (see Internet archive link for archival version).
Derived from site: In situ; Brain, cerebellum; UBERON=UBERON_0002037.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North1.21
East Asian, South0
South Asian0.49
European, North68.21
European, South30.09
Disease Medulloblastoma, non-WNT/non-SHH, group 3 (NCIt: C129445)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 3Y5M
Category Cancer cell line
STR profile Source(s): ATCC=HTB-187; CCRID=1101HUM-PUMC000102

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133817
D3S135816,18
D5S81811,12
D7S8209,13
D8S117914
D13S31711,13
D16S53912,14
D18S5112,17
D19S43313
D21S1130,31
F13A016,7
F13B8,10
FESFPS10,13
FGA19,23
LPL11
Penta D9,13
Penta E8,15
TH016,9.3
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Web pages Info; ATCC; -; https://web.archive.org/web/20160611152450/http://www.atcc.org:80/products/all/HTB-187.aspx#specifications
Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/MedulloD341_Crawford_protocol.pdf
Publications

PubMed=3279793; PMCID=PMC1880676
Henry Seth Friedman, Peter C. Burger, Sandra H. Bigner, John Quinn Trojanowski, Garrett M. Brodeur, Xuan-Min He, Carol J. Wikstrand, Joanne Kurtzberg, Michael E. Berens, Edward Charles Halperin, Darell Doty Bigner;
Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc.
Am. J. Pathol. 130:472-484(1988)

PubMed=2180567
Sandra H. Bigner, Henry Seth Friedman, Bert Vogelstein, W. Jerry Oakes, Darell Doty Bigner;
Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.
Cancer Res. 50:2347-2350(1990)

PubMed=1822845
Carol J. Wikstrand, Henry Seth Friedman, Darell Doty Bigner;
Medulloblastoma cell-substrate interaction in vitro.
Invasion Metastasis 11:310-324(1991)

PubMed=8275086; DOI=10.1038/ng1193-230
Naomi Galili, Richard J. Davis, William J. Fredericks, Sunil Mukhopadhyay, Frank J. Rauscher 3rd, Beverly S. Emanuel, Giovanni Rovera, Frederic G. Barr;
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
Nat. Genet. 5:230-235(1993)

DOI=10.1007/0-306-46861-1_11
Francis Ali-Osman;
Brain tumors.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999)

PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123
Ann-Catrin Andersson, Sara Stromberg, Helena Backvall, Caroline Kampf, Mathias Uhlen, Kenneth Wester, Fredrik Ponten;
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J. Histochem. Cytochem. 54:1413-1423(2006)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20847082; DOI=10.1093/neuonc/noq091; PMCID=PMC3018940
Natalia Teider, Deborah K. Scott, Adrianne Neiss, Shyamal Dilhan Weeraratne, Vladimir M. Amani, Yi-Fei Wang, Victor E. Marquez, Yoon-Jae Cho, Scott L. Pomeroy;
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Neuro-oncol. 12:1244-1256(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Delyan P. Ivanov, Beth Coyle, David A. Walker, Anna M. Grabowska;
In vitro models of medulloblastoma: choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004; PMCID=PMC5079239
Delyan P. Ivanov, David A. Walker, Beth Coyle, Anna M. Grabowska;
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31963405; DOI=10.3390/cancers12010226; PMCID=PMC7016648
Arianna Casciati, Mirella Tanori, Remi Manczak, Sofiane Saada, Barbara Tanno, Paola Giardullo, Elena Porcu, Elena Rampazzo, Luca Persano, Giampietro Viola, Claire Dalmay ...Show all 15 authors... , Fabrice Lalloue, Arnaud Pothier, Caterina Merla, Mariateresa Mancuso; Show fewer authors
Human medulloblastoma cell lines: investigating on cancer stem cell-like phenotype.
Cancers (Basel) 12:226.1-226.14(2020)

Cross-references
Cell line collections (Providers) ATCC; HTB-187
CLS; 305136
KCB; KCB 2010239YJ
Cell line databases/resources CLO; CLO_0002677
cancercelllines; CVCL_0018
CCRID; 1101HUM-PUMC000102
Cell_Model_Passport; SIDM01492
DepMap; ACH-000095
IGRhCellID; D341Med
Biological sample resources BioSample; SAMN03472737
BioSample; SAMN10988120
ENCODE; ENCBS254AAA
CRISP screens repositories BioGRID_ORCS_Cell_line; 689
Chemistry resources ChEMBL-Cells; CHEMBL3308450
ChEMBL-Targets; CHEMBL614478
PharmacoDB; D341Med_280_2019
PubChem_Cell_line; CVCL_0018
Encyclopedic resources Wikidata; Q54817217
Experimental variables resources EFO; EFO_0002157
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2770
GEO; GSM383763
GEO; GSM482333
GEO; GSM827339
GEO; GSM886970
GEO; GSM888039
GEO; GSM918117
GEO; GSM919358
GEO; GSM1008577
Polymorphism and mutation databases Cosmic; 923657
Cosmic; 973263
Cosmic; 974282
Cosmic; 975025
Cosmic; 1097759
Cosmic; 2362652
Cosmic; 2731178
Cosmic; 2772984
IARC_TP53; 30029
LiGeA; CCLE_586
Progenetix; CVCL_0018
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number39