ID   D341 Med
AC   CVCL_0018
SY   D-341 Med; D-341 MED; D-341 Med-C; D-341Med; D-341MED; D341_Med; D341Med; D341MED; D341MD; D-341; D341; Med 341; H341
DR   CLO; CLO_0002677
DR   EFO; EFO_0002157
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; HTB-187
DR   BioGRID_ORCS_Cell_line; 689
DR   BioSample; SAMN03472737
DR   BioSample; SAMN10988120
DR   cancercelllines; CVCL_0018
DR   CCRID; 1101HUM-PUMC000102
DR   Cell_Model_Passport; SIDM01492
DR   ChEMBL-Cells; CHEMBL3308450
DR   ChEMBL-Targets; CHEMBL614478
DR   CLS; 305136
DR   Cosmic; 923657
DR   Cosmic; 973263
DR   Cosmic; 974282
DR   Cosmic; 975025
DR   Cosmic; 1097759
DR   Cosmic; 2362652
DR   Cosmic; 2731178
DR   Cosmic; 2772984
DR   DepMap; ACH-000095
DR   ENCODE; ENCBS254AAA
DR   GEO; GSM383763
DR   GEO; GSM482333
DR   GEO; GSM827339
DR   GEO; GSM886970
DR   GEO; GSM888039
DR   GEO; GSM918117
DR   GEO; GSM919358
DR   GEO; GSM1008577
DR   IARC_TP53; 30029
DR   IGRhCellID; D341Med
DR   KCB; KCB 2010239YJ
DR   LiGeA; CCLE_586
DR   PharmacoDB; D341Med_280_2019
DR   Progenetix; CVCL_0018
DR   PubChem_Cell_line; CVCL_0018
DR   Wikidata; Q54817217
RX   DOI=10.1007/0-306-46861-1_11;
RX   PubMed=1822845;
RX   PubMed=2180567;
RX   PubMed=3279793;
RX   PubMed=8275086;
RX   PubMed=20215515;
RX   PubMed=20847082;
RX   PubMed=22460905;
RX   PubMed=27498314;
RX   PubMed=27812533;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31963405;
WW   http://genome.ucsc.edu/ENCODE/protocols/cell/human/MedulloD341_Crawford_protocol.pdf
WW   https://web.archive.org/web/20160611152450/http://www.atcc.org:80/products/all/HTB-187.aspx#specifications
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: ENCODE project common cell types; tier 3.
CC   Population: Caucasian.
CC   Doubling time: 37 hours (ATCC=HTB-187).
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Omics: Transcriptome analysis by serial analysis of gene expression (SAGE).
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=1.21%; East Asian, South=0%; South Asian=0.49%; European, North=68.21%; European, South=30.09% (PubMed=30894373).
CC   Miscellaneous: The values for the STR markers F13A01, F13B, FESFPS and LPL used to be shown on the ATCC website but are no longer displayed (see Internet archive link for archival version).
CC   Derived from site: In situ; Brain, cerebellum; UBERON=UBERON_0002037.
ST   Source(s): ATCC; CCRID
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 11,13
ST   D16S539: 12,14
ST   D18S51: 12,17
ST   D19S433: 13
ST   D21S11: 30,31
ST   D2S1338: 17
ST   D3S1358: 16,18
ST   D5S818: 11,12
ST   D7S820: 9,13
ST   D8S1179: 14
ST   F13A01: 6,7
ST   F13B: 8,10
ST   FESFPS: 10,13
ST   FGA: 19,23
ST   LPL: 11
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 17,18
DI   NCIt; C129445; Medulloblastoma, non-WNT/non-SHH, group 3
DI   ORDO; Orphanet_616; Medulloblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   3Y5M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 36
//
RX   DOI=10.1007/0-306-46861-1_11;
RA   Ali-Osman F.;
RT   "Brain tumors.";
RL   (In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York (1999).
//
RX   PubMed=1822845;
RA   Wikstrand C.J., Friedman H.S., Bigner D.D.;
RT   "Medulloblastoma cell-substrate interaction in vitro.";
RL   Invasion Metastasis 11:310-324(1991).
//
RX   PubMed=2180567;
RA   Bigner S.H., Friedman H.S., Vogelstein B., Oakes W.J., Bigner D.D.;
RT   "Amplification of the c-myc gene in human medulloblastoma cell lines
RT   and xenografts.";
RL   Cancer Res. 50:2347-2350(1990).
//
RX   PubMed=3279793;
RA   Friedman H.S., Burger P.C., Bigner S.H., Trojanowski J.Q.,
RA   Brodeur G.M., He X.-M., Wikstrand C.J., Kurtzberg J., Berens M.E.,
RA   Halperin E.C., Bigner D.D.;
RT   "Phenotypic and genotypic analysis of a human medulloblastoma cell
RT   line and transplantable xenograft (D341 Med) demonstrating
RT   amplification of c-myc.";
RL   Am. J. Pathol. 130:472-484(1988).
//
RX   PubMed=8275086; DOI=10.1038/ng1193-230;
RA   Galili N., Davis R.J., Fredericks W.J., Mukhopadhyay S.,
RA   Rauscher F.J. III, Emanuel B.S., Rovera G., Barr F.G.;
RT   "Fusion of a fork head domain gene to PAX3 in the solid tumour
RT   alveolar rhabdomyosarcoma.";
RL   Nat. Genet. 5:230-235(1993).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=20847082; DOI=10.1093/neuonc/noq091;
RA   Teider N., Scott D.K., Neiss A., Weeraratne S.D., Amani V.M., Wang Y.-F.,
RA   Marquez V.E., Cho Y.-J., Pomeroy S.L.;
RT   "Neuralized1 causes apoptosis and downregulates Notch target genes in
RT   medulloblastoma.";
RL   Neuro-oncol. 12:1244-1256(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028;
RA   Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.;
RT   "In vitro models of medulloblastoma: choosing the right tool for the
RT   job.";
RL   J. Biotechnol. 236:10-25(2016).
//
RX   PubMed=27812533; DOI=10.1016/j.dib.2016.10.004;
RA   Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.;
RT   "Data on the number and frequency of scientific literature citations
RT   for established medulloblastoma cell lines.";
RL   Data Brief 9:696-698(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31963405; DOI=10.3390/cancers12010226;
RA   Casciati A., Tanori M., Manczak R., Saada S., Tanno B., Giardullo P.,
RA   Porcu E., Rampazzo E., Persano L., Viola G., Dalmay C., Lalloue F.,
RA   Pothier A., Merla C., Mancuso M.;
RT   "Human medulloblastoma cell lines: investigating on cancer stem
RT   cell-like phenotype.";
RL   Cancers (Basel) 12:226.1-226.14(2020).
//