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Cellosaurus U-266/84 (CVCL_0016)

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Cell line name U-266/84
Synonyms U266-84
Accession CVCL_0016
Resource Identification Initiative To cite this cell line use: U-266/84 (RRID:CVCL_0016)
Comments Part of: Human Protein Atlas, Cell Atlas panel.
Population: Caucasian.
Characteristics: Produces IgE lambda (from parent cell line).
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0566 (U266B1)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=3133230; DOI=10.1002/eji.1830180611
Lars Hellman, Staffan Josephson, Helena Jernberg-Wiklund, Kenneth Nilsson, Ulf Pettersson;
Immunoglobulin synthesis in the human myeloma cell line U-266 expression of two immunoglobulin heavy chain isotypes (epsilon and alpha) after long-term cultivation in vitro.
Eur. J. Immunol. 18:905-910(1988)

PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123
Ann-Catrin Andersson, Sara Stromberg, Helena Backvall, Caroline Kampf, Mathias Uhlen, Kenneth Wester, Fredrik Ponten;
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J. Histochem. Cytochem. 54:1413-1423(2006)

Cross-references
Cell line databases/resources cancercelllines; CVCL_0016
Encyclopedic resources Wikidata; Q54973558
Gene expression databases GEO; GSM7701400
GEO; GSM7701401
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number25