ID   U-266/84
AC   CVCL_0016
SY   U266-84
DR   cancercelllines; CVCL_0016
DR   GEO; GSM7701400
DR   GEO; GSM7701401
DR   Wikidata; Q54973558
RX   PubMed=3133230;
RX   PubMed=16957166;
CC   Part of: Human Protein Atlas, Cell Atlas panel.
CC   Population: Caucasian.
CC   Characteristics: Produces IgE lambda (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
CC   Omics: Proteomics; Expression; Large antibody panel staining analysis.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: Plasma cell; CL=CL_0000786.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0566 ! U266B1
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 25
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RX   PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123;
RA   Andersson, Ann-Catrin
RA   Stromberg, Sara
RA   Backvall, Helena
RA   Kampf, Caroline
RA   Uhlen, Mathias
RA   Wester, Kenneth
RA   Ponten, Fredrik
RT   "Analysis of protein expression in cell microarrays: a tool for
RT   antibody-based proteomics.";
RL   J. Histochem. Cytochem. 54:1413-1423(2006).
//
RX   PubMed=3133230; DOI=10.1002/eji.1830180611;
RA   Hellman, Lars
RA   Josephson, Staffan
RA   Jernberg-Wiklund, Helena
RA   Nilsson, Kenneth
RA   Pettersson, Ulf
RT   "Immunoglobulin synthesis in the human myeloma cell line U-266;
RT   expression of two immunoglobulin heavy chain isotypes (epsilon and
RT   alpha) after long-term cultivation in vitro.";
RL   Eur. J. Immunol. 18:905-910(1988).
//