| Publication number |
CLPUB00793 |
|---|
| Authors |
Foulkes W.D., Zhu J., Majewski J. |
|---|
| Title |
Exploring the pathogenic and therapeutic implications of aberrant splicing in breast cancer. |
|---|
| Citation |
(In misc. document) Report for award W81XWH-08-1-0402. Defense Technical Information Center document ADA561072; pp.1-21; DTIC; Fort Belvoir; USA (2011) |
|---|
| Web pages |
https://apps.dtic.mil/sti/citations/ADA561072 |
|---|
| Abstract |
In this proposal, we set out to a) systematically monitor splicing variant
profiles in breast cancer susceptibility genes and b) explore the role of
alternative splicing in breast chemotherapy using a global strategy. In
doing so, we hope to identify and validate candidate splicing variants
involved in tumorigenesis. Although the original the molecular barcode
strategy was not implemented, we have made significant findings in two
areas: 1) we have identified over 1400 new splice variants and have shown
that they are more prevalent in BRCA1-related breast cancer and 2) we have
identified 3 novel fusion proteins. Perhaps most importantly, we have
trained two young bioinformaticians, who both have bright futures in
cancer research.
|
|---|
| Cell lines |
CVCL_UB97; MBC647 CVCL_UB98; MPC298 CVCL_UB99; MPC600 CVCL_UC01; MPC960 CVCL_UC00; MPC7105 |
|---|
