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Cellosaurus publication CLPUB00600

Publication number CLPUB00600
Authors Coriell L.L., Greene A.E., Mulivor R.A.
Title The human genetic mutant cell repository: list of genetic variants, chromosomal aberrations and normal cell cultures submitted to the repository. 6th edition. October 1979.
Citation (In) Institute for Medical Research (Camden, N.J.) NIH 80-2011; pp.1-168; National Institutes of Health; Bethesda (1979)
Web pages https://books.google.ch/books?id=jN43Iv1U38cC
Abstract Since its inception in 1972, an increasing number of investi-gators have utilized the Human Genetic Mutant Cell Repository as a source of contaminant free, verified, biochemically mutant or chromosomally aberrant cell cultures. This increased demand is illustrated on the following two pages. A newly instituted utilization survey indicates that these cell cultures are in demand in almost every discipline of biomedical research. In 1979, the Repository has continued its efforts to assure the high quality of cell cultures established and shipped: lymphoblast cell cultures are being established from over 90% of the heparinized blood specimens received, the collection is continually reviewed and cell cultures are added or deleted as better cultures become available, advanced equipment has been added for programmed freezing and liquid nitrogen storage, and a new shipping container employed during the cold winter months has guaranteed that over 94% of the cell cultures shipped via air mail arrive in good condition. The sixth edition of the catalog includes a number of changes which make it more informative and easier to use. These changes include: a simplified table of contents, a section on use of the catalog, a new format, a Repository number versus page number index, a comprehensive list of references, and improvements to the alphabetical diagnosis index. As submissions to the Repository approach 3,600 specimens it is becoming increasingly difficult to justify the addition of an inadequately documented line to the collection. For this reason, as much information as is available to support the clinical diagnosis as well as a detailed pedigree should accompany the submission of a specimen. This is especially important in the case of disorders with unknown biochemical defects. Several collections have been judged complete and, unless a specimen represents a unique opportunity i.e., blood and skin from the same individual, a family unit, or a variant, the specimen may not be banked. Improving the quality and characterization of the existing collection will take precedence over expanding its size.
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