| Publication number |
CLPUB00531 |
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| Authors |
Li Cheng, Jing-Shun Kong, Qin-Lin Huang, Xiao-Ling Xiong; |
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| Title |
Studies on leukemogenic activity of cell-free extract of mouse SRS-82 cell line. |
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| Citation |
Zhongguo Bing Li Sheng Li Za Zhi 4:9-11(1988) |
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| Web pages |
https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD8589&filename=ZBLS198801004&uniplatform=OVERSEA |
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| Abstract |
Ultrastructural studies of SRS-82 cell line demonstrated certain
morphologic characteristics of lymphocytes and the presence of
intracistenal type A virus in the cytoplasm. Inoculation of cell-free
extract from SRS-82 cell line into 24 newborn mice of Kunmin strain,
leukemias were induced in 15 mice (62.5%). Among them 14 are lymphocytic
(14/15) and only one is myelocytic (1/15). The average induction period
was 169 days. Furthermore, on transfer of ultracentifugation precipitate
suspension of SRS-82 culture supernate into 16 newborn mice of Kunmin
strain, the incidence of leukemia was 250% (all were lymphocytic). The
results showed that both the cell-free extract and culture supernate from
mouse SRS-82 cell line were leukemogenic. The relationship between the
virus and the type of leukemia induced remains to be studied.
|
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| Cell lines |
CVCL_XA35; SRS-82 |
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