| Abstract |
A heterogeneitic human gastric cancer cell line was isolated and
established as a UMK-1 line. Eight clones were selected for studies on
morphology, growth pattern, cellular DNA and RNA contents and drug
sensitivity in comparison with those in parent cell line of UMK-1. There
were differences in morphology, growth pattern, saturation density,
cloning efficiency and cellular DNA and RNA contents among the 8 clones.
The drug sensitivity to mitomycine C (MMC), adriamycine (ADM) and cis-
diamindichloroplatinum (CDDP) varied in each of the clones although that
of UMK-1 line had been in-between them. Such is a reflection of a presence
of clonal heterogeneity. Selection of drugs time by time offers the
greatest effectiveness on tumor regression due to responses to accidental
loss of sensitivity to drugs used.
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