| Publication number |
CLPUB00480 |
|---|
| Authors |
C. Chiu-Yang Shih, Robert L. Truitt, Peter Abramoff, Mortimer Mandell Bortin; |
|---|
| Title |
Relationship between IL-2 receptors and cyclosporine-induced suppression of T leukemia and T helper cells. |
|---|
| Citation |
Transplant. Proc. 15 Suppl. 11:2394-2397(1983) |
|---|
| Abstract |
Cyclosporine A (CsA), an immuno-suppressive agent, has been shown to
preferentially abrogate cell-mediated immune responses, presumably by
blocking early events in T helper cell activation. T-cell suppression by
CsA has been shown to be reversed by the addition of exogenous interleukin
2 (IL-2). Although many studies have shown the cytostatic effects of CsA
on T-malignant cells, little has been done to compare the mechanisms of
suppression on malignant vs. normal T cells. We have therefore undertaken
studies on the effects of CsA on IL-2-dependent and IL-2-independent tumor
cells and on T helper cell clones in order to elucidate the mechanism of
suppression by CsA.
|
|---|
| Cell lines |
CVCL_VU13; A9.12 CVCL_VV44; AKIL-1.E8 CVCL_VV47; AKIL-3.H5 CVCL_VV49; AKIL-6.A3 CVCL_VV50; AKIL-6.D12 CVCL_VV45; AKIL-20 |
|---|
