| Publication number |
CLPUB00413 |
|---|
| Authors |
Satoshi Ikushima, Takao Yoshihara, Fumihiro Fujikawa, Shinjiro Todo, Shin-ichi Misawa, Hitoshi Nakagawa, Keiko Yumura, Keisei Kawa-Ha, Yoshihito Morioka, Shinsaku Imashuku; |
|---|
| Title |
Establishment of a monocytoid cell line (KP-MO-TS) from a patient with acute monocytic leukemia and a mediastinal mass. |
|---|
| Citation |
Acta Haematol. Jpn. 53:678-687(1990) |
|---|
| Web pages |
https://eurekamag.com/research/007/312/007312820.php |
|---|
| Abstract |
A monocytoid cell line (KP-MO-TS) has been established from the peripheral
blood of a patient with acute monocytic leukemia (AMoL). The cells,
showing monoblastoid or promonocytoid morphology, expressed CD15, CD33,
CD4 and HLA-DR antigens. Retinoic acid and 12-O-tetradecanoyl phorbol-13-
acetate induced maturation of the cells into monocytoid or macrophage-like
cells. The expression of CD11b and/or CD13 and an increase in phagocytic
activity accompanied the morphological differentiation. Cytogenetic
studies revealed t(10;11)(p13:q21), the same abnormality initially found
in the patient's leukemic blasts. Immunoglobulin (Ig) kappa gene was
rearranged, however, the IgH gene, T cell-receptor beta and gamma genes
showed germ line configuration. This cell line may be useful in
investigating the biological features and the pathogenesis of monocytic
leukemia possessing a breakpoint at 11q21-23.
|
|---|
| Cell lines |
CVCL_7985; KP-MO-TS |
|---|
