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Cellosaurus publication CLPUB00395
| Publication number | CLPUB00395 |
|---|---|
| Authors | Metewo Selase Enuameh, Lysa-Anne Volpe, Michael Jackson, John Foulke, Lu-Ping Chen, Brian A. Shapiro, Fang Tian; |
| Title | The generation of an EML4-ALK fusion NSCLC isogenic cell line relevant for drug discovery and development. |
| Citation | (In technical document) ATCC application note 25; pp.1-4; ATCC; Manassas; USA (2016) |
| Web pages | https://www.atcc.org/resources/application-notes/generation-of-an-eml4-alk-fusion-nsclc-isogenic-cell-line |
| Abstract | Gene editing tools such as CRISPR/Cas9 can be used to create isogenic cell lines, which can be further used to model a specific patient population for identifying novel, personalized treatment regimens. An isogenic cell line was created to model cancer patients with the echinoderm microtubule- associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion oncogene, a key oncogenic driver, and then tested for its sensitivity to known selective inhibitors of ALK. |
| Cell lines | CVCL_JK07; A549 EML4-ALK |