| Publication number |
CLPUB00375 |
|---|
| Authors |
Kamamoto T., Sakoda H., Taniguchi Y., Kamesaki H., Kita K., Ohno H., Fukuhara S., Umadome Y., Ohkubo T., Yoshida Y., Uchino H. |
|---|
| Title |
Establishment and characterization of an Epstein-Barr virus-negative B cell lymphoma cell line with a 14q+ chromosome abnormality. |
|---|
| Citation |
Naika Hokan 32:241-251(1985) |
|---|
| Web pages |
https://eurekamag.com/research/005/384/005384527.php |
|---|
| Abstract |
A cell line (KPB-L2) was established from the peripheral blood of a
patient with diffuse Burkitt type lymphoma in a leukemic state. KPB-L2
expressed immunoglobulin M-kappa. on the surface as did the primary
tumors and the original leukemic cells. KPB-L2 also expressed Ia-like
antigen but lacked Epstein-Barr virus nuclear antigen. It exhibited a 14q+
marker chromosome, which was a result of a translocation between the
long arms of chromosomes 8 and 14 [t(8;14)(q24;q32)], and the same 14q+
translocation was also found in the parental cells. This cell line may be
useful for studying the significance of 14q+ rearrangement in the
development of lymphoid malignancy.
|
|---|
| Cell lines |
CVCL_W861; KPB-L2 |
|---|
