| Publication number |
CLPUB00118 |
|---|
| Authors |
Pu P.-Y., Zhong Y., Wang S.L., Li P., Wang G.X., Hu Y.L. |
|---|
| Title |
The establishment and comparison of the characteristics of primary and recurrent human malignant astrocytoma cell lines TJ8510 and TJ861. |
|---|
| Citation |
Chin. J. Neurosurg. 8:38-41(1992) |
|---|
| Web pages |
https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHSW199201019.htm |
|---|
| Abstract |
Permanent cell lines TJ8510 and TJ861 derived from the original and
recurrent malignant astrocytoma in the same case respectively have been
established and characterized. There were same malignant character in both
lines. As compared to the characteristics of original cell line (TJ8510),
it was found that the surface structures of the recurrent cell (TJ861)
were more complicated and had much more microvilli and globoid processes
on surfaces in ultrastructural examination and showed a higher S phase
fraction and colony forming efficiency. Most of the cells had a marker
chromosome 11/1q and their model chromosome number was hypertriploid. The
cells were resistant to BCNU as high as 50mug/ml. It is suggested that the
stem cells of the recurrent malignant astrocytoma might grow from those
original malignant tumor cells which were more proliferative, highly
aggressive and had stronger resistance to BCNU.
|
|---|
| Cell lines |
CVCL_B265; TJ8510 CVCL_B266; TJ861 |
|---|
