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Cellosaurus ZR75B Tx10 (CVCL_ZZ28)

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Cell line name ZR75B Tx10
Accession CVCL_ZZ28
Resource Identification Initiative To cite this cell line use: ZR75B Tx10 (RRID:CVCL_ZZ28)
Comments Population: Caucasian.
Doubling time: 34.1 hours (PubMed=8562478; PubMed=9815641).
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5614 (ZR-75-B)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=8562478
Katja Wosikowski, Joanna T. Regis, Robert W. Robey, Manuel Alvarez, Jeroen Titus Maria Buters, Jean Marie Gudas, Susan E. Bates;
Normal p53 status and function despite the development of drug resistance in human breast cancer cells.
Cell Growth Differ. 6:1395-1403(1995)

PubMed=9815641
Katja Wosikowski, Danita H. Schuurhuis, Geert J.P.L. Kops, Miguel Saceda, Susan E. Bates;
Altered gene expression in drug-resistant human breast cancer cells.
Clin. Cancer Res. 3:2405-2414(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZZ28
Encyclopedic resources Wikidata; Q102115157
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number8