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Cellosaurus MDA-MB-453 Ad15 (CVCL_ZZ23)

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Cell line name MDA-MB-453 Ad15
Accession CVCL_ZZ23
Resource Identification Initiative To cite this cell line use: MDA-MB-453 Ad15 (RRID:CVCL_ZZ23)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Doubling time: 120.5 hours (PubMed=9815641).
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: Metastatic; Pericardial effusion; UBERON=UBERON_0002409.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Gln868His (c.2604G>T); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:1748; CDH1; Simple; p.Trp638Ter (c.1913G>A); ClinVar=VCV000599651; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu307Lys (c.919G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Unexplicit; Ex10-11del; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0418 (MDA-MB-453)
Sex of cell Female
Age at sampling 48Y
Category Cancer cell line
Publications

PubMed=9815641
Katja Wosikowski, Danita H. Schuurhuis, Geert J.P.L. Kops, Miguel Saceda, Susan E. Bates;
Altered gene expression in drug-resistant human breast cancer cells.
Clin. Cancer Res. 3:2405-2414(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZZ23
Encyclopedic resources Wikidata; Q102114522
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number8