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Cellosaurus MCF-7 Tx8 (CVCL_ZZ21)

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Cell line name MCF-7 Tx8
Accession CVCL_ZZ21
Resource Identification Initiative To cite this cell line use: MCF-7 Tx8 (RRID:CVCL_ZZ21)
Comments Population: Caucasian.
Doubling time: 54.7 hours (PubMed=9815641).
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=9815641
Katja Wosikowski, Danita H. Schuurhuis, Geert J.P.L. Kops, Miguel Saceda, Susan E. Bates;
Altered gene expression in drug-resistant human breast cancer cells.
Clin. Cancer Res. 3:2405-2414(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZZ21
Encyclopedic resources Wikidata; Q102114503
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number7