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Cellosaurus MCF-7 TH (CVCL_ZZ16)

[Text version]
Cell line name MCF-7 TH
Synonyms MCF-7/TH; MCF-7TH; MCF7/TH; MCF7TH; MCF7Th
Accession CVCL_ZZ16
Resource Identification Initiative To cite this cell line use: MCF-7 TH (RRID:CVCL_ZZ16)
Comments Problematic cell line: Contaminated. Shown to be a OVCAR-8 derivative (PubMed=10995814). Originally thought to be a derivative of MCF-7.
Population: Caucasian.
Doubling time: 50.6 hours (PubMed=8562478; PubMed=9815641).
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Gln26Arg (c.77A>G); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3430; ERBB2; Simple; p.Gly776Val (c.2327G>T); ClinVar=VCV000163410; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Pro121His (c.362C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Homozygous; Note=Splice acceptor mutation (PubMed=8562478).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1629 (OVCAR-8)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line

Wosikowski K., Regis J.T., Robey R.W., Alvarez M., Buters J.T.M., Gudas J.M., Bates S.E.
Normal p53 status and function despite the development of drug resistance in human breast cancer cells.
Cell Growth Differ. 6:1395-1403(1995)

Wosikowski K., Schuurhuis D., Kops G.J.P.L., Saceda M., Bates S.E.
Altered gene expression in drug-resistant human breast cancer cells.
Clin. Cancer Res. 3:2405-2414(1997)

PubMed=10995814; DOI=10.1093/jnci/92.18.1535
Pirnia F., Breuleux M., Schneider E., Hochmeister M., Bates S.E., Marti A., Hotz M.A., Betticher D.C., Borner M.M.
Uncertain identity of doxorubicin-resistant MCF-7 cell lines expressing mutated p53.
J. Natl. Cancer Inst. 92:1535-1536(2000)

PubMed=14871996; DOI=10.1158/1078-0432.CCR-1044-3
Hu Y.-P., Krishan A., Nie W.-J., Sridhar K.S., Mayer L.D., Bally M.
Synergistic cytotoxicity of pyrazoloacridine with doxorubicin, etoposide, and topotecan in drug-resistant tumor cells.
Clin. Cancer Res. 10:1160-1169(2004)

Cell line databases/resources cancercelllines; CVCL_ZZ16
Encyclopedic resources Wikidata; Q102114500
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number5