Cellosaurus Hep-2045 (CVCL_ZY41)
| Cell line name | Hep-2045 |
|---|---|
| Synonyms | Hep2045 |
| Accession | CVCL_ZY41 |
| Resource Identification Initiative | To cite this cell line use: Hep-2045 (RRID:CVCL_ZY41) |
| Comments | Characteristics: The CCDN1, CDK4 and TERT genes expression can be silenced by administration of tetracycline/doxycycline through a Tet-Off system (PubMed=33060611). Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1582; CCND1. Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1773; CDK4 (Note=With p.Arg24Cys). Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR. Genetic integration: Method=Transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del). Derived from site: In situ; Liver; UBERON=UBERON_0002107. Cell type: Hepatocyte; CL=CL_0000182. |
| Disease | Biliary atresia (NCIt: C34421) Isolated biliary atresia (ORDO: Orphanet_30391) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Sex of cell | Male |
| Age at sampling | 5Y |
| Category | Telomerase immortalized cell line |
| Publications | PubMed=33060611; DOI=10.1038/s41598-020-73992-3; PMCID=PMC7567112 |
| Cross-references | |
| Encyclopedic resources | Wikidata; Q102114121 |
| Entry history | |
| Entry creation | 29-Oct-2020 |
| Last entry update | 19-Dec-2024 |
| Version number | 8 |