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Cellosaurus Hep-2004 (CVCL_ZY36)

[Text version]
Cell line name Hep-2004
Synonyms Hep2004
Accession CVCL_ZY36
Resource Identification Initiative To cite this cell line use: Hep-2004 (RRID:CVCL_ZY36)
Comments Characteristics: The CCDN1, CDK4 and TERT genes expression can be silenced by administration of tetracycline/doxycycline through a Tet-Off system (PubMed=33060611).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1582; CCND1.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1773; CDK4 (Note=With p.Arg24Cys).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Hepatocyte; CL=CL_0000182.
Disease Biliary atresia (NCIt: C34421)
Isolated biliary atresia (ORDO: Orphanet_30391)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Telomerase immortalized cell line
Publications

PubMed=33060611; DOI=10.1038/s41598-020-73992-3; PMCID=PMC7567112
Nishiwaki M., Toyoda M., Oishi Y., Ishida S., Horiuchi S.-i., Makino-Itou H., Kimura T., Ohno S.-i., Ohkura T., Enosawa S., Akutsu H., Nakazawa A., Kasahara M., Kiyono T., Umezawa A.
Immortalization of human hepatocytes from biliary atresia with CDK4(R24C), cyclin D1, and TERT for cytochrome P450 induction testing.
Sci. Rep. 10:17503.1-17503.13(2020)

Cross-references
Encyclopedic resources Wikidata; Q102114114
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number8