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Cellosaurus PC-3-TxR (CVCL_ZX05)

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Cell line name PC-3-TxR
Accession CVCL_ZX05
Resource Identification Initiative To cite this cell line use: PC-3-TxR (RRID:CVCL_ZX05)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0035 (PC-3)
Children:
CVCL_ZX06 (PC-3-TxR/CxR)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=17440963; DOI=10.1002/pros.20581
Masashi Takeda, Atsushi Mizokami, Kiminori Mamiya, You-Qiang Li, Jian Zhang, Evan T. Keller, Mikio Namiki;
The establishment of two paclitaxel-resistant prostate cancer cell lines and the mechanisms of paclitaxel resistance with two cell lines.
Prostate 67:955-967(2007)

PubMed=29662635; DOI=10.18632/oncotarget.24609; PMCID=PMC5882326
Kazuaki Machioka, Kouji Izumi, Yoshifumi Kadono, Hiroaki Iwamoto, Renato Naito, Tomoyuki Makino, Suguru Kadomoto, Ariunbold Natsagdorj, Evan T. Keller, Jian Zhang, Atsushi Mizokami;
Establishment and characterization of two cabazitaxel-resistant prostate cancer cell lines.
Oncotarget 9:16185-16196(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZX05
Encyclopedic resources Wikidata; Q102114738
Entry history
Entry creation29-Oct-2020
Last entry update10-Apr-2025
Version number8