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Cellosaurus XP115LO 2 hTERT (CVCL_ZS67)

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Cell line name XP115LO 2 hTERT
Synonyms hTERT-GM02359; GM02359-hTERT; hTERT-XPV; XP115LO.hTERT
Accession CVCL_ZS67
Resource Identification Initiative To cite this cell line use: XP115LO 2 hTERT (RRID:CVCL_ZS67)
Comments Population: Iranian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:9181; POLH; Simple; p.Gln373Ter (c.1117C>T); ClinVar=VCV000005890; Zygosity=Homozygous (from parent cell line).
Disease Xeroderma pigmentosum variant type (NCIt: C141367)
Xeroderma pigmentosum variant (ORDO: Orphanet_90342)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7358 (XP115LO 2)
Sex of cell Male
Age at sampling 25Y
Category Telomerase immortalized cell line
Publications

PubMed=10655550; DOI=10.1093/hmg/9.3.403
Michel M. Ouellette, Lisa D. McDaniel, Woodring Erik Wright, Jerry W. Shay, Roger A. Schultz;
The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes.
Hum. Mol. Genet. 9:403-411(2000)

PubMed=17409408; DOI=10.1158/0008-5472.CAN-06-3073
Yun Wang, Roger Woodgate, Terrence P. McManus, Samantha Mead, J. Justin McCormick, Veronica M. Maher;
Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations.
Cancer Res. 67:3018-3026(2007)

Cross-references
Encyclopedic resources Wikidata; Q98135228
Entry history
Entry creation02-Jul-2020
Last entry update14-Aug-2025
Version number9