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Cellosaurus K562 NGLY1 KO c15 (CVCL_ZL53)

[Text version]
Cell line name K562 NGLY1 KO c15
Synonyms K562 NGLY1 KO clone 15; NGLY1c15
Accession CVCL_ZL53
Resource Identification Initiative To cite this cell line use: K562 NGLY1 KO c15 (RRID:CVCL_ZL53)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:17646; NGLY1.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=31659326; DOI=10.1038/s41592-019-0614-5
Arne H. Smits, Frederik Ziebell, Gerard Joberty, Nico Zinn, William F. Mueller, Sandra Clauder-Munster, Dirk Eberhard, Maria Falth Savitski, Paola Grandi, Petra Jakob, Anne-Marie Michon ...Show all 18 authors... , Hanice Sun, Karen Tessmer, Tilmann Burckstummer, Marcus Bantscheff, Lars M. Steinmetz, Gerard Drewes, Wolfgang Huber; Show fewer authors
Biological plasticity rescues target activity in CRISPR knock outs.
Nat. Methods 16:1087-1093(2019)

Cross-references
Encyclopedic resources Wikidata; Q98126811
Gene expression databases ArrayExpress; E-MTAB-7061
Proteomic databases PRIDE; PXD010335
Entry history
Entry creation02-Jul-2020
Last entry update10-Apr-2025
Version number10