| Comments |
Microsatellite instability: Stable (MSS) (Sanger). Omics: Genomics; DNA methylation analysis. Omics: Genomics; Whole exome sequencing. Omics: Genomics; Whole genome sequencing; Low read coverage. Omics: Phenotyping; CRISPR screening. Omics: Phenotyping; Drug screening. Omics: Proteomics; Expression; Reverse-phase protein array. Omics: Proteomics; Quantitative. Omics: Transcriptomics; Microarray. Omics: Transcriptomics; RNAseq. Omics: Variations; SNP array analysis. Derived from site: In situ; Pharynx, hypopharynx; UBERON=UBERON_0001051. Cell type: Epithelial cell; CL=CL_0000066. |
| Sequence variations |
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.151-1G>T; ClinVar=VCV000422058; Zygosity=Homozygous; Note=Splice acceptor mutation (ATCC=HTB-43; Cosmic-CLP=906863; DepMap=ACH-000846).
- Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Lys3277Asnfs*4 (c.9828delG) (p.Gly3276fs); Zygosity=Heterozygous (Cosmic-CLP=906863; DepMap=ACH-000846).
- Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Heterozygous; Note=Splice acceptor mutation (PubMed=1394225; PubMed=11799138; PubMed=23613873; ATCC=HTB-43; Cosmic-CLP=906863; DepMap=ACH-000846).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Heterozygous (PubMed=1394225; PubMed=11799138; PubMed=23613873; ATCC=HTB-43; Cosmic-CLP=906863; DepMap=ACH-000846).
|
| HLA typing |
Source: PubMed=26589293
| Class I | | HLA-A | A*01:01,01:01 | | HLA-B | B*15:17,37:04 | | HLA-C | C*07:01,07:01 |
|
| Genome ancestry |
Source: PubMed=30894373
| Origin | % genome |
|---|
|
| African | 2.06 | | Native American | 0 | | East Asian, North | 11.01 | | East Asian, South | 0 | | South Asian | 79.51 | | European, North | 0 | | European, South | 7.42 |
|
| Disease |
Hypopharyngeal squamous cell carcinoma (NCIt: C4043) Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547) |
| Species of origin |
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
(NCBI Taxonomy: 9606) |
| Sex of cell |
Male |
| Age at sampling |
56Y |
| Category |
Cancer cell line |
| STR profile |
Source(s): ATCC=HTB-43; Cosmic-CLP=906863; DSMZ=ACC-784; KCLB=30043; PubMed=21868764; PubMed=25877200; PubMed=33802339; PubMed=36912284; Technion Genomics Center
Markers:| Amelogenin | X (KCLB=30043) Not_detected (ATCC=HTB-43; Cosmic-CLP=906863; DSMZ=ACC-784; PubMed=21868764; PubMed=25877200; PubMed=33802339; PubMed=36912284; Technion Genomics Center) |
| CSF1PO | 12 |
| D10S1248 | 15,17 |
| D12S391 | 17,21 |
| D13S317 | 8,9 (ATCC=HTB-43; PubMed=21868764; PubMed=25877200; PubMed=33802339; PubMed=36912284; Technion Genomics Center) 9 (DSMZ=ACC-784) |
| D16S539 | 11 (ATCC=HTB-43; Cosmic-CLP=906863; PubMed=21868764; PubMed=25877200; PubMed=33802339; PubMed=36912284; Technion Genomics Center) 11,12 (DSMZ=ACC-784) |
| D18S51 | 16 |
| D19S433 | 14,16 |
| D1S1656 | 16,16.3 |
| D21S11 | 31 (DSMZ=ACC-784) 31.2 (ATCC=HTB-43; PubMed=25877200; PubMed=33802339; Technion Genomics Center) |
| D22S1045 | 11 |
| D2S1338 | 19 |
| D2S441 | 11 |
| D3S1358 | 17,18 |
| D5S818 | 12 |
| D7S820 | 11,12 |
| D8S1179 | 13 |
| FGA | 25 |
| Penta D | 11 |
| Penta E | 17,19 |
| TH01 | 8 |
| TPOX | 11 |
| vWA | 15,17 (ATCC=HTB-43; Cosmic-CLP=906863; KCLB=30043; PubMed=21868764; PubMed=25877200; PubMed=36912284; Technion Genomics Center) 15,17,18 (DSMZ=ACC-784; PubMed=33802339) |
Run an STR similarity search on this cell line |
| Entry history |
| Entry creation | 04-Apr-2012 |
| Last entry update | 25-Jun-2026 |
| Version number | 50 |
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