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Cellosaurus HEK293-CAGA (CVCL_ZD63)

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Cell line name HEK293-CAGA
Synonyms HEK293 (CAGA)12
Accession CVCL_ZD63
Resource Identification Initiative To cite this cell line use: HEK293-CAGA (RRID:CVCL_ZD63)
Comments Characteristics: Robustly responds to signaling by activin and TGF-beta class ligands and employed in an assay measuring inhibition of ligand activity (PubMed=23543431).
Characteristics: Luciferase reporter gene expression is under the control of a promoter containing a Smad binding element (SBE) (CAGA(12)).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0045 (HEK293)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=22052913; DOI=10.1074/jbc.M111.270801; PMCID=PMC3256893
Jennifer N. Cash, Elizabeth B. Angerman, Chandramohan Kattamuri, Kristof Nolan, Hua-Ying Zhao, Yisrael Sidis, Henry Todd Keutmann, Thomas B. Thompson;
Structure of myostatin/follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding.
J. Biol. Chem. 287:1043-1053(2012)

PubMed=22593183; DOI=10.1210/me.2012-1061; PMCID=PMC3385792
Jennifer N. Cash, Elizabeth B. Angerman, Henry Todd Keutmann, Thomas B. Thompson;
Characterization of follistatin-type domains and their contribution to myostatin and activin A antagonism.
Mol. Endocrinol. 26:1167-1178(2012)

PubMed=23543431; DOI=10.1177/1087057113482585
Jennifer N. Cash, Elizabeth B. Angerman, R. Jason Kirby, Lisa Merck, William L. Seibel, Matthew D. Wortman, Ruben Papoian, Sandra Nelson, Thomas B. Thompson;
Development of a small-molecule screening method for inhibitors of cellular response to myostatin and activin A.
J. Biomol. Screen. 18:837-844(2013)

Cross-references
Encyclopedic resources Wikidata; Q98126665
Entry history
Entry creation02-Jul-2020
Last entry update14-Aug-2025
Version number7