| Cell line name |
MOC22 |
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| Synonyms |
Mouse Oral Cancer 22 |
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| Accession |
CVCL_ZD36 |
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| Resource Identification Initiative |
To cite this cell line use: MOC22 (RRID:CVCL_ZD36) |
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| Comments |
Characteristics: Indolent growth phenotype.
Transformant: ChEBI; CHEBI_254496; 7,12-dimethyltetraphene (DMBA; dimethylbenzanthracene).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray. |
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| Sequence variations |
- Mutation; MGI; MGI:96224; Hras; Simple; p.Gln61Leu (c.182A>T); Zygosity=Unspecified (PubMed=22086849).
- Mutation; MGI; MGI:98834; Trp53; Simple; p.Thr122Pro; Zygosity=Unspecified (PubMed=24668645).
- Mutation; MGI; MGI:98834; Trp53; Simple; p.Lys384Ter; Zygosity=Unspecified (PubMed=24668645).
|
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| Disease |
Squamous cell carcinoma of the mouse oral cavity (NCIt: C23049) |
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| Species of origin |
Mus musculus (Mouse)
(NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6. |
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| Sex of cell |
Female |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): Kerafast=EWL003-FP; Millipore=SCC471
Markers:| Mouse STR 1-1 | 15 |
| Mouse STR 1-2 | 19 |
| Mouse STR 2-1 | 16 |
| Mouse STR 3-2 | 14 |
| Mouse STR 4-2 | 20.3 |
| Mouse STR 5-5 | 17 (Kerafast=EWL003-FP)
17,18 (Millipore=SCC471) |
| Mouse STR 6-4 | 19 |
| Mouse STR 6-7 | 15 |
| Mouse STR 7-1 | 26.2 |
| Mouse STR 8-1 | 16 |
| Mouse STR 11-2 | 16 |
| Mouse STR 12-1 | 17 |
| Mouse STR 13-1 | 17 |
| Mouse STR 15-3 | 22.3 |
| Mouse STR 17-2 | 15 |
| Mouse STR 18-3 | 15,16 (Millipore=SCC471)
16 (Kerafast=EWL003-FP) |
| Mouse STR 19-2 | 13 |
| Mouse STR X-1 | 27 |
Run an STR similarity search on this cell line |
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| Publications | PubMed=22086849; DOI=10.1158/0008-5472.CAN-11-1831; PMCID=PMC3286642
Nancy P. Judd, Ashley E. Winkler, Oihana Murillo-Sauca, Joshua J. Brotman, Jonathan H. Law, James S. Lewis Jr., Gavin P. Dunn, Jack D. Bui, John B. Sunwoo, Ravindra Uppaluri;
ERK1/2 regulation of CD44 modulates oral cancer aggressiveness.
Cancer Res. 72:365-374(2012) PubMed=24668645; DOI=10.1158/1078-0432.CCR-14-0205; PMCID=PMC4096804
Michael D. Onken, Ashley E. Winkler, Krishna-Latha Kanchi, Varun Chalivendra, Jonathan H. Law, Charles G. Rickert, Dorina Kallogjeri, Nancy P. Judd, Gavin P. Dunn, Jay Francis Piccirillo, James S. Lewis Jr. ...Show all 13 authors... , Elaine R. Mardis, Ravindra Uppaluri; Show fewer authors
A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease.
Clin. Cancer Res. 20:2873-2884(2014) PubMed=25729643; DOI=10.1016/j.gdata.2014.11.006; PMCID=PMC4340082
Varun Chalivendra, Krishna-Latha Kanchi, Michael D. Onken, Ashley E. Winkler, Elaine R. Mardis, Ravindra Uppaluri;
Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer.
Genom. Data 3:61-62(2015) |
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| Cross-references |
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| Cell line collections (Providers) |
Kerafast; EWL003-FP
Millipore; SCC471
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| Encyclopedic resources |
Wikidata; Q98127275
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| Gene expression databases |
GEO; GSM1213089
GEO; GSM1213090
GEO; GSM1213091
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| Entry history |
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| Entry creation | 02-Jul-2020 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 10 |
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