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Cellosaurus RKO SIRT1 KO (CVCL_ZC46)

[Text version]
Cell line name RKO SIRT1 KO
Accession CVCL_ZC46
Resource Identification Initiative To cite this cell line use: RKO SIRT1 KO (RRID:CVCL_ZC46)
Comments From: Li, Xiao-Ling; National Institute of Environmental Health Sciences, NIH; Bethesda; USA.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:14929; SIRT1.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Cross-references
Cell line collections (Providers) Kerafast; ENH132-FP
Cell line databases/resources cancercelllines; CVCL_ZC46
Encyclopedic resources Wikidata; Q98128927
Entry history
Entry creation02-Jul-2020
Last entry update19-Dec-2024
Version number8