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Cellosaurus HT TRAF6 KD (CVCL_ZC30)

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Cell line name HT TRAF6 KD
Synonyms TRAF6 Knock Down HT
Accession CVCL_ZC30
Resource Identification Initiative To cite this cell line use: HT TRAF6 KD (RRID:CVCL_ZC30)
Comments Population: Caucasian.
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:12036; TRAF6.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val216Met (c.646G>A); ClinVar=VCV000182965; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
Disease Diffuse large B-cell lymphoma germinal center B-cell type (NCIt: C36080)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1290 (HT)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
Publications

PubMed=30165192; DOI=10.1016/j.canlet.2018.08.020
Chang-Ju Qu, Kranthi Kunkalla, Amineh Vaghefi, John K. Frederiksen, Ya-Dong Liu, Jennifer Rose Chapman, Marzenna Blonska, Leon Bernal-Mizrachi, Juan Pablo Alderuccio, Izidore S. Lossos, Ralf Landgraf, Francisco Vega-Vazquez;
Smoothened stabilizes and protects TRAF6 from degradation: a novel non-canonical role of smoothened with implications in lymphoma biology.
Cancer Lett. 436:149-158(2018)

Cross-references
Cell line collections (Providers) Kerafast; EMI026
Cell line databases/resources cancercelllines; CVCL_ZC30
Encyclopedic resources Wikidata; Q98126737
Entry history
Entry creation02-Jul-2020
Last entry update19-Dec-2024
Version number8