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Cellosaurus K562-GEM (CVCL_Z735)

[Text version]
Cell line name K562-GEM
Synonyms K562/Gem; K/gem
Accession CVCL_Z735
Resource Identification Initiative To cite this cell line use: K562-GEM (RRID:CVCL_Z735)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_175901; Gemcitabine (Gemzar).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=10500836; DOI=10.1007/978-1-4615-4811-9_63
Charles Dumontet, Evelyne Callet-Bauchu, Krystyna Aniela Fabianowska-Majewska, Michel Lepoivre, Dorota Wyczechowska, Frederique Bodin, Marie-Odile Rolland;
Common resistance mechanisms to nucleoside analogues in variants of the human erythroleukemic line K562.
Adv. Exp. Med. Biol. 457:571-577(1999)

PubMed=11802204; DOI=10.1002/ijc.1628
Carlos Maria Galmarini, Marilyn L. Clarke, Nicole Falette, Alain Puisieux, John R. Mackey, Charles Dumontet;
Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine.
Int. J. Cancer 97:439-445(2002)

Cross-references
Encyclopedic resources Wikidata; Q54899384
Entry history
Entry creation10-Apr-2015
Last entry update19-Dec-2024
Version number17