| Cell line name |
MCF-7/MDD2 |
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| Synonyms |
MDD2 |
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| Accession |
CVCL_Z704 |
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| Resource Identification Initiative |
To cite this cell line use: MCF-7/MDD2 (RRID:CVCL_Z704) |
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| Comments |
Population: Caucasian.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0031 (MCF-7) |
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| Sex of cell |
Female |
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| Age at sampling |
69Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=8700512
Sarah S. Bacus, Yosef Yarden, Moshe Oren, Dot M. Chin, Ljuba Lyass, Carolyn R. Zelnick, Alexander Kazarov, Wendy M. Toyofuku, Julie Gray-Bablin, Roger R. Beerli, Nancy Elizabeth Hynes ...Show all 15 authors... , Mikhail A. Nikiforov, Rebecca Haffner, Andrei V. Gudkov, Khandan Keyomarsi; Show fewer authors
Neu differentiation factor (Heregulin) activates a p53-dependent pathway in cancer cells.
Oncogene 12:2535-2547(1996) PubMed=11802204; DOI=10.1002/ijc.1628
Carlos Maria Galmarini, Marilyn L. Clarke, Nicole Falette, Alain Puisieux, John R. Mackey, Charles Dumontet;
Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine.
Int. J. Cancer 97:439-445(2002) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_Z704
|
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| Encyclopedic resources |
Wikidata; Q54904375
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| Entry history |
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| Entry creation | 10-Apr-2015 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 14 |
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