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Cellosaurus C6/36 (CVCL_Z230)

[Text version]

Cell line name C6/36
Synonyms Clone C6/36; Aedes albopictus clone C6/36; ATC-15(C6/36); AAL-C6/36; C6-36; SAAR-C6/36
Accession CVCL_Z230
Resource Identification Initiative To cite this cell line use: C6/36 (RRID:CVCL_Z230)
Comments Group: Insect cell line.
Characteristics: Used for detection, propagation and analysis of mosquito-borne viruses.
Characteristics: Not susceptible to SARS coronavirus 2 (SARS-CoV-2) infection (COVID-19) (PubMed=33389257).
Omics: Deep quantitative proteome analysis.
Omics: Genome sequenced.
Species of origin Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) (NCBI Taxonomy: 7160)
Hierarchy Parent: CVCL_Z223 (ATC-15)
CVCL_B3N5 (C6/36-HE8 )CVCL_VH42 (C6/36-HT )
Sex of cell Sex unspecified
Age at sampling Neonate larva
Category Spontaneously immortalized cell line
Web pages https://pt.wikipedia.org/wiki/C6/36

PubMed=690610; DOI=10.1099/0022-1317-40-3-531
Igarashi A.
Isolation of a Singh's Aedes albopictus cell clone sensitive to Dengue and Chikungunya viruses.
J. Gen. Virol. 40:531-544(1978)

Herrera R.J.
Cytological, cytogenetic and biochemical studies on several permanent insect cell lines.
Thesis PhD (1982), Fordham University, United States

PubMed=6126429; DOI=10.1007/BF02796333
Brown S.E., Knudson D.L.
Characterization of invertebrate cell lines. IV. Isozyme analyses of dipteran and acarine cell lines.
In Vitro 18:347-350(1982)

PubMed=6137452; DOI=10.1007/BF02628962
Kuno G.
Cultivation of mosquito cell lines in serum-free media and their effects on dengue virus replication.
In Vitro 19:707-713(1983)

Kuno G., Gubler D.J., Velez M., Oliver A.
Comparative sensitivity of three mosquito cell lines for isolation of dengue viruses.
Bull. World Health Organ. 63:279-286(1985)

PubMed=3611315; DOI=10.1128/JCM.25.7.1221-1224.1987
White L.A.
Susceptibility of Aedes albopictus C6/36 cells to viral infection.
J. Clin. Microbiol. 25:1221-1224(1987)

PubMed=2563994; DOI=10.1007/BF02626177
Kuno G., Oliver A.
Maintaining mosquito cell lines at high temperatures: effects on the replication of flaviviruses.
In Vitro Cell. Dev. Biol. 25:193-196(1989)

PubMed=19951376; DOI=10.1111/j.1365-2672.2009.04621.x
Voronin D.A., Tran-Van V., Potier P., Mavingui P.
Transinfection and growth discrepancy of Drosophila Wolbachia strain wMel in cell lines of the mosquito Aedes albopictus.
J. Appl. Microbiol. 108:2133-2141(2010)

PubMed=20976219; DOI=10.1371/journal.pone.0013398
Frentiu F.D., Robinson J., Young P.R., McGraw E.A., O'Neill S.L.
Wolbachia-mediated resistance to dengue virus infection and death at the cellular level.
PLoS ONE 5:E13398-E13398(2010)

PubMed=28404849; DOI=10.1128/JVI.00554-17
Xin Q.-L., Deng C.-L., Chen X., Wang J., Wang S.-B., Wang W., Deng F., Zhang B., Xiao G.-F., Zhang L.-K.
Quantitative proteomic analysis of mosquito C6/36 cells reveals host proteins involved in Zika virus infection.
J. Virol. 91:e00554.17-e00554.17(2017)

PubMed=29329394; DOI=10.1093/gigascience/gix135
Miller J.R., Koren S., Dilley K.A., Puri V., Brown D.M., Harkins D.M., Thibaud-Nissen F., Rosen B., Chen X.-G., Tu Z., Sharakhov I.V., Sharakhova M.V., Sebra R., Stockwell T.B., Bergman N.H., Sutton G.G., Phillippy A.M., Piermarini P.M., Shabman R.S.
Analysis of the Aedes albopictus C6/36 genome provides insight into cell line utility for viral propagation.
GigaScience 7:gix135.1-gix135.13(2018)

PubMed=29973702; DOI=10.1038/s41598-018-28357-2
Gaburro J., Duchemin J.-B., Paradkar P.N., Nahavandi S., Bhatti A.
Electrophysiological evidence of RML12 mosquito cell line towards neuronal differentiation by 20-hydroxyecdysdone.
Sci. Rep. 8:10109-10109(2018)

PubMed=33389257; DOI=10.1007/s10096-020-04106-0
Wurtz N., Penant G., Jardot P., Duclos N., La Scola B.
Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity, and differences in growth profile.
Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021)

Cell line collections ATCC; CRL-1660
BCRC; 60114
BCRJ; 0343
ECACC; 89051705
JCRB; IFO50010
KCB; KCB 82002YJ
NCBI_Iran; C612
Cell line databases/resources CLO; CLO_0001672
CLO; CLO_0002506
CLDB; cl799
Anatomy/cell type resources BTO; BTO:0005452
Encyclopedic resources Wikidata; Q54808220
Proteomic databases PRIDE; PXD004727
Entry history
Entry creation10-Apr-2015
Last entry update22-Sep-2022
Version number18