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Cellosaurus ISE6 (CVCL_Z170)

[Text version]
Cell line name ISE6
Accession CVCL_Z170
Resource Identification Initiative To cite this cell line use: ISE6 (RRID:CVCL_Z170)
Comments Group: Patented cell line.
Group: Tick cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11974.
Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).
Omics: Deep proteome analysis.
Omics: Metabolome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Whole embryo; UBERON=UBERON_0000922.
Species of origin Ixodes scapularis (Black-legged tick) (Deer tick) (NCBI Taxonomy: 6945)
Sex of cell Sex unspecified
Age at sampling Embryo
Category Spontaneously immortalized cell line
Web pages https://www.liverpool.ac.uk/health-and-life-sciences/research/liverpool-shared-research-facilities/bio-resources/tick-cell-biobank/tick-cell-lines/

PubMed=8812616; DOI=10.1006/jipa.1996.0050
Kurtti T.J., Munderloh U.G., Andreadis T.G., Magnarelli L.A., Mather T.N.
Tick cell culture isolation of an intracellular prokaryote from the tick Ixodes scapularis.
J. Invertebr. Pathol. 67:318-321(1996)

Munderloh U.G., Kurtti T.J., Kocan K.M., Blouin E.F., Ewing S.A.
Propagating bovine parasite by incubation of undifferentiated cells under low oxygen increased carbon dioxide, with organic buffers efficient, large scale production; diagnosis/vaccine for rocky mountains spotted fever.
Patent number US5869335, 09-Feb-1999

PubMed=16922866; DOI=10.1111/j.1462-5822.2006.00727.x
Singu V., Peddireddi L., Sirigireddy K.R., Cheng C.-M., Munderloh U.G., Ganta R.R.
Unique macrophage and tick cell-specific protein expression from the p28/p30-outer membrane protein multigene locus in Ehrlichia chaffeensis and Ehrlichia canis.
Cell. Microbiol. 8:1475-1487(2006)

PubMed=17662657; DOI=10.1016/j.pt.2007.07.009
Bell-Sakyi L., Zweygarth E., Blouin E.F., Gould E.A., Jongejan F.
Tick cell lines: tools for tick and tick-borne disease research.
Trends Parasitol. 23:450-457(2007)

PubMed=19242658; DOI=10.1007/s10493-009-9255-1
Billeter S.A., Diniz P.P.V.P., Battisti J.M., Munderloh U.G., Breitschwerdt E.B., Levy M.G.
Infection and replication of Bartonella species within a tick cell line.
Exp. Appl. Acarol. 49:193-208(2009)

PubMed=22743047; DOI=10.1016/j.ttbdis.2012.05.002
Alberdi M.P., Dalby M.J., Rodriguez-Andres J., Fazakerley J.K., Kohl A., Bell-Sakyi L.
Detection and identification of putative bacterial endosymbionts and endogenous viruses in tick cell lines.
Ticks Tick Borne Dis. 3:137-146(2012)

PubMed=25894426; DOI=10.1007/s10493-015-9908-1
Oliver J.D., Oliva Chavez A.S., Felsheim R.F., Kurtti T.J., Munderloh U.G.
An Ixodes scapularis cell line with a predominantly neuron-like phenotype.
Exp. Appl. Acarol. 66:427-442(2015)

PubMed=26424601; DOI=10.1074/mcp.M115.051938
Villar M., Ayllon N., Alberdi M.P., Moreno A., Moreno M., Tobes R., Mateos-Hernandez L., Weisheit S., Bell-Sakyi L., de la Fuente J.
Integrated metabolomics, transcriptomics and proteomics identifies metabolic pathways affected by Anaplasma phagocytophilum infection in tick cells.
Mol. Cell. Proteomics 14:3154-3172(2015)

PubMed=29886187; DOI=10.1016/j.ttbdis.2018.05.015
Bell-Sakyi L., Darby A.C., Baylis M., Makepeace B.L.
The Tick Cell Biobank: a global resource for in vitro research on ticks, other arthropods and the pathogens they transmit.
Ticks Tick Borne Dis. 9:1364-1371(2018)

PubMed=32158404; DOI=10.3389/fphys.2020.00152
Al-Rofaai A., Bell-Sakyi L.
Tick cell lines in research on tick control.
Front. Physiol. 11:152.1-152.7(2020)

PubMed=33389257; DOI=10.1007/s10096-020-04106-0
Wurtz N., Penant G., Jardot P., Duclos N., La Scola B.
Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity, and differences in growth profile.
Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021)

Cell line collections (Providers) ATCC; CRL-3576
BEI_Resources; NR-12234
Encyclopedic resources Wikidata; Q54898276
Proteomic databases PRIDE; PXD002181
Entry history
Entry creation10-Apr-2015
Last entry update02-May-2024
Version number14