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Cellosaurus 293T/ACE2 [USA 2003] (CVCL_YZ65)

[Text version]
Cell line name 293T/ACE2 [USA 2003]
Accession CVCL_YZ65
Resource Identification Initiative To cite this cell line use: 293T/ACE2 [USA 2003] (RRID:CVCL_YZ65)
Comments Group: SARS-CoV-2 research cell line.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:13557; ACE2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA).
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0063 (HEK293T)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=14647384; DOI=10.1038/nature02145; PMCID=PMC7095016
Wen-Hui Li, Michael J. Moore, Natalya Vasilieva, Jian-Hua Sui, Swee Kee Wong, Michael A. Berne, Mohan Somasundaran, John L. Sullivan, Katherine Luzuriaga, Thomas C. Greenough, Hyeryun Choe, Michael Reynolds Farzan;
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Nature 426:450-454(2003)

Cross-references
Encyclopedic resources Wikidata; Q98125378
Entry history
Entry creation02-Jul-2020
Last entry update14-Aug-2025
Version number10