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Cellosaurus A549 DHODH-/- (CVCL_YZ46)

[Text version]
Cell line name A549 DHODH-/-
Synonyms DHODH-/- A549
Accession CVCL_YZ46
Resource Identification Initiative To cite this cell line use: A549 DHODH-/- (RRID:CVCL_YZ46)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:2867; DHODH.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=32754890; DOI=10.1007/s13238-020-00768-w; PMCID=PMC7402641
Rui Xiong, Lei-Ke Zhang, Shi-Liang Li, Yuan Sun, Min-Yi Ding, Yong Wang, Yong-Liang Zhao, Yan Wu, Wei-Juan Shang, Xia-Ming Jiang, Ji-Wei Shan, Zi-Hao Shen, Yi Tong ...Show all 25 authors... , Liu-Xin Xu, Yu Chen, Ying-Le Liu, Gang Zou, Dimitri Lavillete, Zhen-Jiang Zhao, Rui Wang, Li-Li Zhu, Geng-Fu Xiao, Ke Lan, Hong-Lin Li, Ke Xu; Show fewer authors
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Protein Cell 11:723-739(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YZ46
Encyclopedic resources Wikidata; Q98125454
Entry history
Entry creation02-Jul-2020
Last entry update19-Dec-2024
Version number7