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Cellosaurus HPDE-iKRASwt (CVCL_YY29)

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Cell line name HPDE-iKRASwt
Accession CVCL_YY29
Resource Identification Initiative To cite this cell line use: HPDE-iKRASwt (RRID:CVCL_YY29)
Comments Characteristics: Expression the KRAS gene is under the control of doxycycline.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6407; KRAS.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Donor information: Established from a patient suffering from a cystadenocarcinoma in the tail of her pancreas.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Cell type: Pancreatic ductal cell; CL=CL_0002079.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0P37 (HPDE6c11)
Sex of cell Female
Age at sampling 63Y
Category Transformed cell line
Publications

PubMed=26806015; DOI=10.1038/ncomms10500; PMCID=PMC4737758
Yiu Huen Tsang, Turgut Dogruluk, Philip M. Tedeschi, Joanna Wardwell-Ozgo, Heng-Yu Lu, Maribel Espitia, Nikitha Nair, Rosalba Minelli, Ze-Chen Chong, Feng-Ju Chen, Qing Edward Chang ...Show all 24 authors... , Jennifer B. Dennison, Armel Dogruluk, Min Li, Hao-Qiang Ying, Joseph Rocco Bertino, Marie-Claude Gingras, Michael Ittmann, John Kerrigan, Ken Chen, Chad Jeremy Creighton, Agda Karina Eterovic, Gordon B. Mills, Kenneth L. Scott; Show fewer authors
Functional annotation of rare gene aberration drivers of pancreatic cancer.
Nat. Commun. 7:10500.1-10500.11(2016)

Cross-references
Encyclopedic resources Wikidata; Q98126698
Entry history
Entry creation02-Jul-2020
Last entry update14-Aug-2025
Version number13