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Cellosaurus T47D-LTED (CVCL_YX85)

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Cell line name T47D-LTED
Synonyms T47D LTED; T47D-Long Term Estrogen-Deprived
Accession CVCL_YX85
Resource Identification Initiative To cite this cell line use: T47D-LTED (RRID:CVCL_YX85)
Comments Population: Caucasian.
Characteristics: Derived from parent cell line by long-term culture in the presence of RPMI 1640 medium containing 10% dextran charcoal stripped serum (DCC) (PubMed=26116361).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu194Phe (c.580C>T); ClinVar=VCV000127817; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0553 (T-47D)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=26116361; DOI=10.1158/1535-7163.MCT-15-0143
Ricardo Ribas, Sunil Pancholi, Stephanie K. Guest, Elisabetta Marangoni, Qiong Gao, Aurelie Thuleau, Nikiana Simigdala, Urszula M. Polanska, Hayley Campbell, Aradhana Rani, Gianmaria Liccardi ...Show all 15 authors... , Stephen R.D. Johnston, Barry Robert Davies, Mitch Dowsett, Lesley-Ann Martin; Show fewer authors
AKT antagonist AZD5363 influences estrogen receptor function in endocrine-resistant breast cancer and synergizes with fulvestrant (ICI182780) in vivo.
Mol. Cancer Ther. 14:2035-2048(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YX85
Encyclopedic resources Wikidata; Q98133073
Entry history
Entry creation12-Mar-2020
Last entry update10-Apr-2025
Version number10