| Cell line name |
MCF7-LTED |
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| Synonyms |
MCF7 LTED; LTED-I; MCF7-Long Term Estrogen-Deprived |
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| Accession |
CVCL_YX84 |
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| Resource Identification Initiative |
To cite this cell line use: MCF7-LTED (RRID:CVCL_YX84) |
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| Comments |
Population: Caucasian.
Characteristics: Derived from parent cell line by long-term culture in the presence of RPMI 1640 medium containing 10% dextran charcoal stripped serum (DCC) (PubMed=26116361).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0031 (MCF-7) |
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| Sex of cell |
Female |
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| Age at sampling |
69Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=12775708; DOI=10.1074/jbc.M305226200
Lesley-Ann Martin, Ian Farmer, Stephen R.D. Johnston, Simak Ali, Christopher John Marshall, Mitch Dowsett;
Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation.
J. Biol. Chem. 278:30458-30468(2003) PubMed=26116361; DOI=10.1158/1535-7163.MCT-15-0143
Ricardo Ribas, Sunil Pancholi, Stephanie K. Guest, Elisabetta Marangoni, Qiong Gao, Aurelie Thuleau, Nikiana Simigdala, Urszula M. Polanska, Hayley Campbell, Aradhana Rani, Gianmaria Liccardi ...Show all 15 authors... , Stephen R.D. Johnston, Barry Robert Davies, Mitch Dowsett, Lesley-Ann Martin; Show fewer authors
AKT antagonist AZD5363 influences estrogen receptor function in endocrine-resistant breast cancer and synergizes with fulvestrant (ICI182780) in vivo.
Mol. Cancer Ther. 14:2035-2048(2015) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_YX84
|
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| Encyclopedic resources |
Wikidata; Q95986792
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| Entry history |
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| Entry creation | 12-Mar-2020 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 11 |
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