Cellosaurus cell line PDXPC1 (CVCL

Cellosaurus PDXPC1 (CVCL_YP13)

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Cell line name

PDXPC1

Accession

CVCL_YP13

Resource Identification Initiative

To cite this cell line use: PDXPC1 (RRID:CVCL_YP13)

Comments

Population: Chinese.
Characteristics: Established from a 3rd generation xenograft obtained by subcutaneously implantation into female BALB/c nude mice of the parent tumor cells.
Doubling time: 37.2 hours (PubMed=32124956).
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.

Sequence variations

Mutation; HGNC; HGNC:4392; GNAS; Simple; p.His69Asn (c.205C>A); Zygosity=Heterozygous (PubMed=32124956).
Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Heterozygous (PubMed=32124956).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (PubMed=32124956).

Disease

Pancreatic ductal adenocarcinoma (NCIt: C9120)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

70Y

Category

Cancer cell line

STR profile

Source(s): PubMed=32124956

Markers:

Amelogenin	X
CSF1PO	9,10
D5S818	9,11
D7S820	10,11,11.3
D13S317	10,11
D16S539	9
TH01	7,9
TPOX	10,12
vWA	15,16,20

Publications

PubMed=32124956; DOI=10.3892/ijo.2020.4965; PMCID=PMC7010221
Xiao-Xiao Du, Kui-Feng He, Ying-Ying Huang, Zhen-Zhen Xu, Mei Kong, Jing Zhang, Jiang Cao, Li-Song Teng;
Establishment of a novel human cell line retaining the characteristics of the original pancreatic adenocarcinoma, and evaluation of MEK as a therapeutic target.
Int. J. Oncol. 56:761-771(2020)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_YP13

Encyclopedic resources

Wikidata; Q98128529

Entry history

Entry creation

12-Mar-2020

Last entry update

10-Apr-2025

Version number