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Cellosaurus Hs578T-delta-hTfR1 (CVCL_YL24)

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Cell line name Hs578T-delta-hTfR1
Synonyms Hs578TdeltahTfR1
Accession CVCL_YL24
Resource Identification Initiative To cite this cell line use: Hs578T-delta-hTfR1 (RRID:CVCL_YL24)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11763; TFRC (Note=3 of 3 alleles).
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012612; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val157Phe (c.469G>T); ClinVar=VCV000012353; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0332 (Hs 578T)
Sex of cell Female
Age at sampling 74Y
Category Cancer cell line
Publications

PubMed=25980759; DOI=10.1186/s12977-015-0168-2; PMCID=PMC4445801
Constantine James Konstantoulas, Benjamin Lamp, Tillman Hans Rumenapf, Stanislav Indik;
Single amino acid substitution (G42E) in the receptor binding domain of mouse mammary tumour virus envelope protein facilitates infection of non-murine cells in a transferrin receptor 1-independent manner.
Retrovirology 12:43.1-43.19(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YL24
Encyclopedic resources Wikidata; Q94301899
Entry history
Entry creation12-Mar-2020
Last entry update19-Dec-2024
Version number10