Cellosaurus cell line LINTERNA MDA-MB-231 (CVCL

Cellosaurus LINTERNA MDA-MB-231 (CVCL_YJ86)

Cross-references
Cell line name	LINTERNA MDA-MB-231
Synonyms	LINTERNA-MDA-MB-231; TurboGFP MDA-MB-231
Accession	CVCL_YJ86
Resource Identification Initiative	To cite this cell line use: LINTERNA MDA-MB-231 (RRID:CVCL_YJ86)
Comments	Group: Triple negative breast cancer (TNBC) cell line. Population: Caucasian. Transfected with: UniProtKB; Q6WV12; Pontellina plumata GFP2 (with p.Lys5Glu, p.Val117Met, p.Val149Asp, p.Val151Asp, p.Ala155Thr, p.Phe168Ser and p.Leu200Asp = TurboGFP). Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR). Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease	Breast adenocarcinoma (NCIt: C5214)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0062 (MDA-MB-231)
Sex of cell	Female
Age at sampling	51Y
Category	Cancer cell line
Cell line collections (Providers)	Innoprot; P20117
Encyclopedic resources	Wikidata; Q95982231
Entry history
Entry creation	19-Dec-2019
Last entry update	29-Jun-2023
Version number	10