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Cellosaurus MCF-7 shWDR12-4 (CVCL_YJ25)

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Cell line name MCF-7 shWDR12-4
Accession CVCL_YJ25
Resource Identification Initiative To cite this cell line use: MCF-7 shWDR12-4 (RRID:CVCL_YJ25)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Doubling time: 16-18 hours (CelloPub=CLPUB00550).
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:14098; WDR12.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

CLPUB00550
Sophie Benhamron;
Validating WDR12 as a potential drug target in triple negative breast cancer.
Thesis MSc (2019); University of Toronto; Toronto; Canada

Cross-references
Cell line databases/resources cancercelllines; CVCL_YJ25
Encyclopedic resources Wikidata; Q95986128
Entry history
Entry creation19-Dec-2019
Last entry update19-Dec-2024
Version number9