Cellosaurus cell line HEK293 RPS2 A226Y (CVCL

Cellosaurus HEK293 RPS2 A226Y (CVCL_YD69)

Cross-references
Cell line name	HEK293 RPS2 A226Y
Accession	CVCL_YD69
Resource Identification Initiative	To cite this cell line use: HEK293 RPS2 A226Y (RRID:CVCL_YD69)
Comments	Characteristics: Transfected with mutated Rps2 linked to IRES-eGFP. Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP). Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:105110; Rps2 (Note=With p.Ala226Tyr). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5. Omics: Metabolomics. Omics: Transcriptomics; RNAseq. Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0045 (HEK293)
Sex of cell	Female
Age at sampling	Fetus
Category	Transformed cell line
Publications	PubMed=31637312; DOI=10.1038/s42003-019-0626-9; PMCID=PMC6797716 Dmitri Shcherbakov, Youjin Teo, Heithem Boukari, Adrian Cortes-Sanchon, Matilde Mantovani, Ivan Osinnii, James Moore, Reda Juskeviciene, Margarita Brilkova, Stefan Duscha, Harshitha Santhosh Kumar ...Show all 16 authors... , Endre Laczko, Hubert Rehrauer, Eric Westhof, Rashid Akbergenov, Erik Christian Bottger; Show fewer authors Ribosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis. Commun. Biol. 2:381.1-381.16(2019)
Encyclopedic resources	Wikidata; Q94094915
Gene expression databases	GEO; GSM3168273 GEO; GSM3168274 GEO; GSM3168275
Metabolomic databases	MetaboLights; MTBLS106
Entry history
Entry creation	19-Dec-2019
Last entry update	14-Aug-2025
Version number	10