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Cellosaurus MDA-MB-231T (CVCL_YA89)

[Text version]
Cell line name MDA-MB-231T
Synonyms MB231T
Accession CVCL_YA89
Resource Identification Initiative To cite this cell line use: MDA-MB-231T (RRID:CVCL_YA89)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Has metastatic potential.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line

PubMed=15870434; DOI=10.1093/jnci/dji111
Palmieri D., Halverson D.O., Ouatas T., Horak C.E., Salerno M., Johnson J., Figg W.D., Hollingshead M.G., Hursting S.D., Berrigan D., Steinberg S.M., Merino M.J., Steeg P.S.
Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer.
J. Natl. Cancer Inst. 97:632-642(2005)

Encyclopedic resources Wikidata; Q95987395
Gene expression databases GEO; GSM1178375
GEO; GSM1178376
Entry history
Entry creation19-Dec-2019
Last entry update29-Jun-2023
Version number6