| Cell line name |
MDA-MB-231T |
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| Synonyms |
MB231T |
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| Accession |
CVCL_YA89 |
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| Resource Identification Initiative |
To cite this cell line use: MDA-MB-231T (RRID:CVCL_YA89) |
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| Comments |
Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Has metastatic potential.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Breast adenocarcinoma (NCIt: C5214) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0062 (MDA-MB-231) |
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| Sex of cell |
Female |
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| Age at sampling |
51Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=15870434; DOI=10.1093/jnci/dji111
Palmieri D., Halverson D.O., Ouatas T., Horak C.E., Salerno M., Johnson J., Figg W.D. Sr., Hollingshead M.G., Hursting S.D., Berrigan D., Steinberg S.M., Merino M.J., Steeg P.S.
Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer.
J. Natl. Cancer Inst. 97:632-642(2005) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_YA89
|
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| Encyclopedic resources |
Wikidata; Q95987395
|
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| Gene expression databases |
GEO; GSM1178375
GEO; GSM1178376
|
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| Entry history |
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| Entry creation | 19-Dec-2019 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 9 |
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