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Cellosaurus HKC-8 (CVCL_Y910)

[Text version]
Cell line name HKC-8
Synonyms HKC8; HKC clone 8
Accession CVCL_Y910
Resource Identification Initiative To cite this cell line use: HKC-8 (RRID:CVCL_Y910)
Comments Doubling time: 20 hours (PubMed=9042817).
Transformant: Ad12-SV40 hybrid virus.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_Y909 ! HKC-5
CVCL_Y911 ! HKC-11
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=9042817; DOI=10.1016/S0022-2143(97)90180-3
Lorraine Claire Racusen, Christelle Monteil, Anita Sgrignoli, Margit Lucskay, Sylviane Marouillat, John G.S. Rhim, Jean-Paul Morin;
Cell lines with extended in vitro growth potential from human renal proximal tubule: characterization, response to inducers, and comparison with established cell lines.
J. Lab. Clin. Med. 129:318-329(1997)

PubMed=11007312; DOI=10.1007/s004240000356
Chiaki Hara, Hiroaki Satoh, Tomohiko Usui, Motoei Kunimi, Eisei Noiri, Kazuhisa Tsukamoto, Shigeo Taniguchi, Shu Uwatoko, Astuo Goto, Lorraine Claire Racusen, Jun Inatomi ...Show all 14 authors... , Hitoshi Endou, Toshiro Fujita, George Seki; Show fewer authors
Intracellular pH regulatory mechanism in a human renal proximal cell line (HKC-8): evidence for Na+/H+ exchanger, CI-/HCO3- exchanger and Na+-HCO3-cotransporter.
Pflugers Arch. 440:713-720(2000)

PubMed=19937734; DOI=10.1002/jcb.22390
Matthew R. Turvey, Yan-Yun Wang, Yu-Chun Gu;
The effects of extracellular nucleotides on [Ca2+]i signalling in a human-derived renal proximal tubular cell line (HKC-8).
J. Cell. Biochem. 109:132-139(2010)

PubMed=31267758; DOI=10.2217/fon-2019-0067
Ines Nogueira, Francisca Dias, Mariana Morais, Ana Luysa Teixeira, Rui Medeiros;
Everolimus resistance in clear cell renal cell carcinoma: miRNA-101 and HIF-2alpha as molecular triggers?
Future Oncol. 15:2361-2370(2019)

PubMed=33122286; DOI=10.1681/ASN.2020010009; PMCID=PMC7894662
Syed J. Khundmiri, Li-He Chen, Eleanor D. Lederer, Chin-Rang Yang, Mark A. Knepper;
Transcriptomes of major proximal tubule cell culture models.
J. Am. Soc. Nephrol. 32:86-97(2021)

Cross-references
Encyclopedic resources Wikidata; Q54889747
Gene expression databases GEO; GSM4009067
GEO; GSM4009068
GEO; GSM4009077
Entry history
Entry creation10-Apr-2015
Last entry update10-Apr-2025
Version number10